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Table 2 Cox Proportional Hazards Models of survival as a function of the molecular phenotypes (SOX2+/CDX2- vs SOX2-/CDX2+) for each clinicopathological parameter

From: Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome

Parameter

Hazard ratio (95% CI)

   
 

Unadjusted

P

Adjusteda

P

Overall

1.95 (1.15-3.31)

0.01

1.90 (1.10-3.28)

0.02

Laurén classification

    

  Intestinal-type

3.18 (1.33-7.58)

0.009

2.93 (1.21-7.10)

0.02

  Diffuse-type

1.35 (0.35-5.17)

0.7

  

  Unclassified

1.34 (0.60-3.02)

0.5

  

Ming classification

    

  Expanding

4.84 (1.64-14.29)

0.004

4.53 (1.29-15.85)

0.02

  Infiltrative

1.13 (0.60-2.13)

0.7

  

Vascular invasion

    

  Negative

3.84 (1.30-11.35)

0.02

3.82 (1.29-11.40)

0.02

  Positive

1.10 (0.60-2.02)

0.8

  

N stage

    

  N0

2.96 (0.82-10.65)

0.1

3.98 (0.72-21.83)

0.1

  N+

1.29 (0.72-2.30)

0.4

  
  1. Abbreviation: CI confidence interval.
  2. a Adjusted for age and gender (Multivariate analysis using the Cox regression model).