Table 6 Expression of β2-M protein in different breast cancer molecular types
From: Characterization of β2-microglobulin expression in different types of breast cancer
Variable | β2-M | p53 | Ki67 | |||
|---|---|---|---|---|---|---|
Positive staining | P-value | Positive staining | P-value | Positive staining | P-value | |
(%) | (%) | (%) | ||||
Breast cancer | 67.68 (111/164) | <0.01 | ||||
Benign breast tumor | 34.14 (42/123) | |||||
Age (years) | ||||||
<59 | 65.87 (83/126) | 0.617 | 38.83 (40/103) | 0.506 | 90.56 (96/106) | 0.130 |
>60 | 70.27 (26/ 37) | 32.15 (10/31) | 80.64 (25/31) | |||
Stage | ||||||
I + II | 61.81 (34/55) | 0.515 | 25.53 (12/47) | 0.227 | 82.97 (39/47) | 0.136 |
III + IV | 68.96 (20/29) | 34.78 (8/23) | 95.65 (22/23) | |||
Lymph node metastasis | ||||||
Present | 67.79 (40/59) | 0.956 | 40.00 (18/45) | 0.279 | 97.82 (45/46) | <0.01 |
Absent | 68.25 (43/63) | 29.62 (16/54) | 79.62 (43/54) | |||
Molecular subtype | ||||||
Luminal A | 56.25 (36/64) | 0.034 | 25.00 (16/64) | <0.01 | 77.41 (48/62) | <0.01 |
Luminal B | 53.33 (16/30) | 32.00 (8/25) | 96.15 (25/26) | |||
Overexpression of HER-2 | 84.61 (22/26) | 70.83 (17/24) | 100.00 (26/26) | |||
Basal-like | 73.68 (14/19) | 38.88 (7/18) | 94.44 (17/18) | |||
ER + | 58.06 (54/93) | <0.01 | 27.05 (23/85) | <0.01 | 82.75 (72/87) | <0.01 |
ER − | 81.39 (35/43) | 56.09 (23/41) | 100.00 (43/43) | |||
HER-2 + | 72.41 (42/58) | 0.180 | 50.98 (26/51) | <0.01 | 98.11 (52/53) | <0.01 |
HER-2 − | 61.62 (53/86) | 28.04 (23/82) | 83.13 (69/83) | |||