Figure 2
From: Characterization of β2-microglobulin expression in different types of breast cancer
Silencing of the β2-M gene by siRNAs in breast cancer cells. A) β2-M siRNAs significantly inhibited the Bcl-2 mRNA expression, but did not inhibit the ER, PR, and HER-2 mRNA expression in MCF-7 cells (ER+, PR+ and HER-2−); B) β2-M siRNAs significantly up-regulated the Bcl-2 and HER-2 mRNA expression in MDA-MB-231 cells (ER−, PR− and HER-2−); C) ER, HER-2, PR and Bcl-2 protein levels in MCF-7 cells, with or without β2-M siRNAs; D) ER, HER-2, PR and Bcl-2 protein levels in MDA-MB-231 cells, with or without β2-M siRNAs.