Table 2 Relationship between clinicopathological parameters and HIPK2 expression in human CRC
From: Verbascoside promotes apoptosis by regulating HIPK2–p53 signaling in human colorectal cancer
Variable | N | Nat different HIPK2 expression levels | χ2 | P | ||||
|---|---|---|---|---|---|---|---|---|
Low expression | High expression | |||||||
− | + | ++ | +++ | |||||
Sex | ||||||||
Male | 47 | 23 | 13 | 7 | 4 | 0.31 | >0.05 | |
Female | 53 | 26 | 12 | 12 | 3 | |||
Age (years) | ||||||||
≤60 | 29 | 11 | 9 | 7 | 2 | 0.88 | >0.05 | |
>60 | 71 | 38 | 16 | 12 | 5 | |||
Maximum diameter of tumor | ||||||||
≤5 | 58 | 30 | 16 | 8 | 4 | 2.02 | >0.05 | |
>5 | 42 | 19 | 9 | 11 | 3 | |||
Degree of differentiation | ||||||||
Well differentiated | 12 | 7 | 2 | 2 | 1 | 6.44 | <0.05 | |
Moderately differentiated | 67 | 33 | 16 | 12 | 6 | |||
Poorly differentiated | 5 | 1 | 4 | 0 | 0 | |||
Depth of invasion | ||||||||
Not invading serosa | 42 | 28 | 7 | 5 | 2 | 4.71 | >0.05 | |
In serosa | 25 | 6 | 9 | 9 | 1 | |||
Outside serosa | 33 | 15 | 9 | 5 | 4 | |||
Duke stage | ||||||||
Stages A and B | 72 | 35 | 19 | 15 | 3 | 0.13 | >0.05 | |
Stages C and D | 28 | 14 | 6 | 4 | 4 | |||
Lymph node status | ||||||||
Metastasis | 65 | 32 | 18 | 12 | 3 | 0.82 | >0.05 | |
No metastasis | 35 | 17 | 7 | 7 | 4 | |||
TNM stage | ||||||||
Stages I and II | 57 | 31 | 14 | 11 | 1 | 1.69 | >0.05 | |
Stages III and IV | 43 | 18 | 11 | 8 | 6 | |||