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Figure 4 | BMC Cancer

Figure 4

From: Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer

Figure 4

Efficacy of axitinib and crizotinib in intact tumor bearing mice by in vivo Faxitron X-ray and ex vivo μCT imaging. (A) Faxitron and μCT imaging in intact mice model. Faxitron images were taken at indicated time intervals during the study, whereas μCT images were taken and reconstructed at the termination of the study (week 9). μCT images show the 3-D of the tibial length and a tibial cross-section. (B) Quantitation of Intra-tibial tumor model in Intact mice: BV/TV ratios were determined by Scanco software after μCT imaging. ** (black) is vehicle vs control leg; * (red) treatment vs vehicle. *p < 0.01; **p < 0.001. Error bars represent SEM of n = 10 mice/group.

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