The CAIRO4 study: the role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer – a randomized phase III study of the Dutch Colorectal Cancer Group (DCCG)

Table 1 Data on resection versus non-resection of the primary tumour in metastatic CRC patients

Study	Years of study	Number of patients		Median survival time (in months)		p-value
		Resection	Non-resection	Resection	Non-resection
Liu[20]	1986-1991	57	5	11	2	n.a.
Ruo[24]	1996-1999	127	103	16	9	<0.001
Kaufman[25]	1998-2003	115	69	22	3	<0.0001
Scoggins[13]	1985-1997	66	23	14.5	16.6	0.59
Tebbutt[26]	1990-1999	280	82	14	8.2	0.08
Michel[27]	1996-1999	31	23	21	14	0.718
Benoist[16]	1997-2002	32	27	23	22	n.a.
Evans[28]	1999-2006	45	57	11	2	< 0.0001
Poultsides[15]	2000-2006	-	178	-	13
Venderbosch[23]	2003-2004	258	141	16.7	11.4	< 0.0001
Venderbosch[23]	2005-2006	289	159	20.7	13.4	<0.0001

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