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Table 1 The percentages of surface receptor- and cytotoxic granule-positive NK-92 cells co-cultured with SW1990 compared to those cultured alone

From: Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunction

 

NK-92 + Medium (%)

NK92 + SW1990 (%)

P-value

NKG2D

94.72 ± 0.49

23.73 ± 2.05

<0.001

NKp30

27.36 ± 0.08

3.81 ± 0.17

<0.001

NKp44

24.33 ± 2.07

0.93 ± 0.48

<0.01

NKp46

11.76 ± 1.14

1.73 ± 1.03

<0.01

DNAM-1

51.35 ± 2.06

2.63 ± 1.13

<0.001

KIR3DL1

2.06 ± 0.65

1.78 ± 1.19

Ns

KIR2DL1/DS1

1.79 ± 0.96

2.50 ± 0.85

Ns

NKp80

92.67 ± 2.74

91.61 ± 2.85

Ns

Perforin

95.68 ± 0.52

40.93 ± 0.49

<0.001

Granzyme B

95.81 ± 1.96

86.24 ± 3.01

<0.01

  1. All experiments were repeated three times. All data were expressed as mean ± SD. Independent t-tests were used for statistical analysis through SPSS 19.0 software. P < 0.01 is considered significant; P < 0.001 is considered highly significant.
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BMC Cancer

ISSN: 1471-2407

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