The effect of MMP-9 and IDO blockers in NK-92 cells cultured alone or with SW1990 cells in the absence or presence of 1-MT and/or TIMP-1. (A) The percentages of NKG2D-, NKp30- and Perforin-positive NK-92 cells in the different NK-92 cell-pancreatic cell treatment groups. (B,
D) Comparisons between these different treatment groups demonstrate that the addition of 1-MT and/or TIMP-1 blockers can partially restore the percentage of positive NK-92 cells. All experiments were repeated three times. All data were expressed as mean ± SD. Independent t-tests were used for statistical analysis through SPSS 19.0 software. *represents P <0.05, **represents P <0.01, and ***represents P <0.001.