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Figure 3 | BMC Cancer

Figure 3

From: Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunction

Figure 3

The expression of COX-2, MMP-9 and IDO in pancreatic cancer cells. (A) Relative expressions of COX-2, MMP-9 and IDO in hTERT-HPNE cells compared to SW1990 cells cultured alone or co-cultured with NK cells. (B and C) The concentrations of IDO and MMP-9 in cell cultural supernatants from NK cells cultured alone, hTERT-HPNE cells cultured alone or co-cultured with NK cells, SW1990 cells cultured aloneor co-cultured with NK cells. (D and E) The corresponding plots for NK-92 cells cultured alone or cultured with SW1990, in the absence or presence of 0.5 mM 1-MT and/or 0.5 ug/ml TIMP-1, show that the concentrations of IDO and MMP-9 can be partially restored by these blockers.All experiments were repeated three times. All data were expressed as mean ± SD. Independent t-tests were used for statistical analysis through SPSS 19.0 software. *represents P <0.05, **represents P <0.01, and ***represents P <0.001.

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