Table 2 Epithelial and stromal expression of COX-2 in breast cancers investigated
ALG 1: percentage fraction of the COX-2 positive cells (0–100) with a mean value of all the results used for recognition of tumour overexpressing the COX-2 protein | ALG 2: percentage fraction of the COX-2 positive cells (0–100) with a cut-off of 10% used for recognition of tumour overexpressing the COX-2 protein | ALG 3: percentage fraction of the COX-2 positive cells (0–100) × staining intensity (1–3) with a median value of all the results used for recognition of tumour overexpressing the COX-2 protein | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Anti-COX-2 antibody | Ab1 | Ab2 | Ab3 | Ab1 | Ab2 | Ab3 | Ab1 | Ab2 | Ab3 | |||||||||
Type of the cells scored (E – epithelial; S – stromal) | E | S | E | S | E | S | E | S | E | S | E | S | E | S | E | S | E | S |
Cut-off value | 5.1 | 4.2 | 21.1 | 9.8 | 43.0 | 19.0 | 10% of the cells with a moderate or strong staining | 6.2 | 8.2 | 27.3 | 15.3 | 68.0 | 30.1 | |||||
Percentage fraction of the tumours overexpressing COX-2 | 41.5 | 41.5 | 51.2 | 39.0 | 46.3 | 48.8 | 0 | 2.4 | 26.8 | 29.3 | 26.8 | 80.5 | 48.8 | 48.8 | 48.8 | 48.8 | 48.8 | 46.3 |