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Table 2 Epithelial and stromal expression of COX-2 in breast cancers investigated

From: Stromal, rather than epithelial cyclooxygenase-2 (COX-2) expression is associated with overall survival of breast cancer patients

  ALG 1: percentage fraction of the COX-2 positive cells (0–100) with a mean value of all the results used for recognition of tumour overexpressing the COX-2 protein ALG 2: percentage fraction of the COX-2 positive cells (0–100) with a cut-off of 10% used for recognition of tumour overexpressing the COX-2 protein ALG 3: percentage fraction of the COX-2 positive cells (0–100) × staining intensity (1–3) with a median value of all the results used for recognition of tumour overexpressing the COX-2 protein
Anti-COX-2 antibody Ab1 Ab2 Ab3 Ab1 Ab2 Ab3 Ab1 Ab2 Ab3
Type of the cells scored (E – epithelial; S – stromal) E S E S E S E S E S E S E S E S E S
Cut-off value 5.1 4.2 21.1 9.8 43.0 19.0 10% of the cells with a moderate or strong staining 6.2 8.2 27.3 15.3 68.0 30.1
Percentage fraction of the tumours overexpressing COX-2 41.5 41.5 51.2 39.0 46.3 48.8 0 2.4 26.8 29.3 26.8 80.5 48.8 48.8 48.8 48.8 48.8 46.3
  1. Staining was evaluated with three different algorithms (ALG1, ALG2 and ALG3) applied to data obtained using three different anti-COX-2 antibodies (Ab1, Ab2 and Ab3).