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Table 1 IC 50 values (μM) for 1, 2, and cisplatin on MCF-7, MDA-MB-231 and HCC1937 cells after 24 h of treatment (data reflect the mean and ± SD of results from three separate experiments, each performed in triplicate)

From: Cellular responses of BRCA1-defective and triple-negative breast cancer cells and in vitro BRCA1 interactions induced by metallo-intercalator ruthenium(II) complexes containing chloro-substituted phenylazopyridine

Metal complexes

IC50(μM)

MCF-7

MDA-MB-231

HCC1937

Cisplatin

42.2 ± 8 *,**

128.2 ± 7 *,**

23.4 ± 7 *,**

1

10.7 ± 0.6 *,**

14.1 ± 0.5 *,**

9.9 ± 0.2 *,**

2

8.2 ± 0.1 *,**

13.2 ± 0.3 *,**

1.8 ± 0.1 *,**

  1. Statistical significance differences are indicated by *p < 0.01, compared the IC50 values of the same complex on cell lines, and **p < 0.01, compared the IC50 values of the complexes on each cell line.
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BMC Cancer

ISSN: 1471-2407

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