Figure 11
The secondary structure and titration curve of the binding of metal complexes to the apo-form of the BRCA1 protein (without Zn 2+ ). (A) The effect of the ruthenium(II) complexes on the secondary structures of proteins was predicted by the CONTIN program. The relative secondary structure of the Ru-BRCA1 adducts at 50 μM of the complexes were plotted. (B) Changes in the ellipticity of the protein at 208 nm with increasing metal concentrations were plotted.