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Table 3 Sensitivity analysis of mortality using multivariable Cox regression techniques

From: Survival in overweight patients with advanced pancreatic carcinoma: a multicentre cohort study

 

Univariable

Multivariable

Variable

HR

95% CI

P-value

HR

95% CI

P-value

BMI

1.30

1.13 - 1.48

<0.001

1.28

1.10. – 1.50

0.001

(in steps of 5)

Age (continuously)

1.00

0.99 - 1.01

0.695

1.00

0.99 - 1.01

0.405

Performance status

0.73

0.60 - 0.94

0.015

0.70

0.54 - 0.91

0.009

(ECOG < 2 versus ECOG ≥ 2)

Diabetes

0.87

0.69 - 1.09

0.234

0.78

0.61 - 1.01

0.064

(yes versus no)

Stage

0.98

0.74 - 1.30

0.912

1.10

0.80 - 1.47

0.601

(stage III versus stage IV)

Sex

1.35

1.10 - 1.66

0.004

1.30

1.04 -1.63

0.023

(male versus female)

CA 19-9

1.08

1.04 - 1.12

<0.001

1.06

1.02 - 1.11

0.006

(continuously on log scale)

  1. Only patients treated with gemcitabine-based first-line therapy were included (N = 407). Abbreviations: BMI body mass index, CI confidence interval, ECOG Eastern Cooperative Oncology Group, HR hazard ratio.