Figure 5

Crystal structures of BRAF domain-inhibitor complexes. (A) BRAF ^WT and T1Q (in yellow), (B) BRAF ^V600E and vemurafenib (in light blue), (C) comparison of binding modes of the two inhibitors, and (D) multiple sequence alignment of crystallized BRAF domains (amino acids residues lacking electron density are represented by dots. The BRAF domain structural regions are colored as follows: green: P-loop; red: hinge region; blue: activation segment; cyan: DGF motif; lime: α-C-helix; magenta: α-E-helix.