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Table 3 Nuclear and cytoplasmic Ep-ICD expression in invasive ductal carcinoma (IDC) and correlation with clinicopathological parameters

From: Nuclear Ep-ICD accumulation predicts aggressive clinical course in early stage breast cancer patients

Clinicopathological parameters Total cases (n = 180) Ep-ICD Nuclear p-value Odd’s ratio (95% C.I.) Ep-ICD Cytoplasm p-value Odd’s ratio (95% C.I.)
   N (%)    n (%)   
IDC cases   75 42 - - 145 81 - -
Age          
< 59 years 88 39 44.3    74 84.1   
≥ 59 years 92 36 39.1 0.480 0.80 (0.45–1.45) 71 77.2 0.241 0.64(0.30–1.36)
Tumor Size a          
≤2 cm 81 35 43.2    69 85.2   
> 2 cm 96 37 38.5 0.529 0.82 (0.45–1.50) 73 76.0 0.128 0.55(0.25–1.20)
T-stage          
T 1 + T 2 171 71 41.5    138 80.7   
T 3 + T 4 9 4 44.4 0.862 1.13 (0.30–4.34) 7 77.8 0.829 0.84(0.17–4.22)
Nodal Status          
N x+0 123 58 47.2    99 80.5   
N 1–3 57 17 29.8 0.028 0.48 (0.24–0.98) 46 80.7 0.973 1.02(0.45–2.24)
Stage          
I + II 159 68 42.8    130 81.8   
III + IV 21 7 33.3 0.410 0.67 (0.26–1.74) 15 71.4 0.261 0.56(0.20–1.56)
Grade b          
I + II 108 53 49.1    90 83.3   
III 65 20 30.8 0.018 0.46 (0.24–0.89) 48 73.8 0.132 0.57(0.27–1.20)
Clinical Recurrence          
No 155 50 32.3    121 78.1   
Yes 25 25 100 <0.001 1.50 (1.28–1.76) 24 96.0 0.035 6.75(0.88–51.67)
ER/ PR status c          
ER + 136 62 45.6    112 82.4   
ER - 33 12 36.4 0.338 1.47 (0.67–3.22) 25 75.8 0.386 1.49(0.60–3.71)
PR + 103 49 47.6    88 85.4   
PR - 64 25 39.1 0.282 1.42 (0.75–2.67) 48 75.0 0.092 1.96(0.89–4.30)
ER + PR + 103 49 47.6    88 85.4   
ER - PR - 33 12 36.4 0.260 1.59(0.70–3.56) 25 75.8 0.197 1.96(0.89–4.30)
  1. aTumor Size was available for 177 IDCs; bTumor Grades were available for 173 IDCs; cER and PR status was available for 169 and 167 IDCs only in our clinical databases. Membranous EpEx expression or loss of Membranous EpEx did not show significant correlation with any clinical or pathological parameters, hence the data are not shown in this Table. The p-value in boldface are statically significant.