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Figure 3 | BMC Cancer

Figure 3

From: Nuclear Ep-ICD accumulation predicts aggressive clinical course in early stage breast cancer patients

Figure 3

Kaplan-Meier curves for disease-free survival (DFS) stratified by nuclear Ep-ICD expression in DCIS and in IDC. A. Nuclear accumulation of Ep-ICD was associated with significantly reduced DFS in DCIS patients (p < 0.001). In 30 patients positive for nuclear Ep-ICD accumulation, 13 recurrences of DCIS were observed. In contrast, no recurrence was observed in 31 patients who did not show nuclear Ep-ICD immunopositivity and these patients were recurrence free for 60 months. B. Nuclear accumulation of Ep-ICD was associated with significantly reduced DFS in IDC patients (p < 0.001). In 75 patients positive for nuclear Ep-ICD accumulation, 25 events were observed. In contrast, no event was observed in 105 patients who did not show nuclear Ep-ICD immunopositivity and patients were alive for 60 months.

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