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Figure 2 | BMC Cancer

Figure 2

From: Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells

Figure 2

RA-resistant MDA-MB-468 cells are sensitized to ATRA by curcumin. (A) MDA-MD-468 cells were plated in 96 well plates, treated with varying dose of curcumin for 48 hours and the control used was DMSO. The % cell proliferation for each of the treatment with curcumin for the designated concentration was calculated with respect to the treatment with DMSO for the corresponding dose. Data are mean of ± SE (n = 3). * p = 0.04 versus control, ** p = 0.04 versus control, # p = 0.02 versus control, # # p = 0.008. (B) MDA-MD-468 cells were plated in 96 well plates, treated with 30 μM curcumin for varying time. The control was DMSO treated according to the timeframe of the cells treated with curcumin. The % cell proliferation for each of the treatment with curcumin for the designated time was calculated with respect to the treatment with DMSO for the corresponding time. Data are mean of ± SE (n = 3). * p = 0.009 versus control, ** p = 0.009 versus control. (C) MDA-MB-468 cells (2500 cells/well) were plated in 96 well plates, treated with 1 μM ATRA (RA), 30 μM curcumin (C), or 30 μM curcumin and 1 μM ATRA for 48 hours. The control was DMSO, ethanol or a combination of both. The % cell proliferation for each of the treatment (curcumin, ATRA or both) was calculated relative to their solvent, DMSO, ethanol or DMSO and ethanol, respectively. The controls were set at 100%. Data are mean of ± SE (n = 4). * p = 0.03 versus curcumin.

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