Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer

BMC Cancer

Table 3 The correlation of mRNA expression of Kiss-1R and clinical parameters

Category		No.	Median	IQR	p
T/N^a
	Normal	80	30	1-2406
	Tumour	94	<0.000001	<0.000001	<0.0001^c
Paired T/N^a
	Paired normal	68	23	0-522
	Paired tumour	68	<0.000001	0-0.02	<0.0001^c
Location
	Left colon	22	<0.000001	<0.000001-0.01
	Right colon	28	<0.000001	<0.000001-0.009	0.8791
	Transcolon^b	2	0.00452	N/A
	Rectum	22	<0.000001	<0.000001-0.13	0.447
Dukes classification
	A	7	0.00015	<0.000001-0.00103
	B	33	0.0004	<0.000001-0.0091	0.6616
	C	32	<0.000001	<0.000001-0.09	0.1431
Tumour stage
	T1	2	1.06E-05	N/A
	T2	10	0.00005	<0.000001-0.00171
	T3	40	<0.000001	<0.000001-0.03
	T4	18	<0.000001	<0.000001-0.02
Lymph node involvement
	Node 0^d	39	0.0003	<0.000001-0.0071
	Node 1^d	16	<0.000001	<0.000001-0.02	0.3236
	Node 2^d	15	0.01	<0.000001-1.76	0.335
TNM staging
	I	9	0.00003	<0.000001-0.00033
	II	30	0.0005	<0.000001-0.0105	0.1939
	III&IV	32	<0.000001	<0.000001-0.09	0.051
Clinical outcome
	No invasion	50	<0.000001	<0.000001-0.008
	Invasion	26	<0.000001	<0.000001-0.05	0.1907
	Disease free	35	0.00019	<0.000001-0.00523
	Incidence	23	0.01	<0.000001-0.12	0.0207^c
	No recurrence	58	<0.000001	<0.000001-0.013
	Local recurrence	7	0.00653	<0.000001-0.02245	0.6923
	No metastasis	50	<0.000001	<0.000001-0.009
	Metastasis	19	<0.000001	<0.000001-0.13	0.0765
	Alive	36	0.00028	<0.000001-0.00724
	Death	22	<0.000001	<0.000001-0.13	0.0158^c
	Non treat	42	0.0002	<0.000001-0.006
	Chemradio	5	0.0796	0.012-0.1607	0.0115^c

^aTumour (T), Normal (N). ^bTransverse colon. ^c p < 0.05. ^dNode 0 stands for no node involvement; Node 1 stands for 1 to 3 lymph nodes close to the bowel found to contain cancer cells; Node 2 stands for more than 3 lymph nodes found to contain cancer cells and further than 3cm away from the main tumor in the bowel or the presence of cancer cells in lymph nodes connected to the main blood vessels around the bowel.

ISSN: 1471-2407