Figure 4
From: Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer
ERK pathway in the Kiss-1 regulated motility of colorectal cancer cells. A. Left: The effect of Kiss-1 and Kiss-1R knockdown on the migration ability of HT115 cells treated withKisspeptin-10 compared with control group (no treatment). Right: Overall changes in resistance at the eighth hour * p < 0.05 vs the respective control group at the specific time point. B. Left: Cells in two different experimental settings (control and Kisspeptin-234) during 8 hours after wounding. Right: Overall changes in resistance at the eighth hour. C. Left: The mean trace of the cells in two groups of experiments (control and ERK inhibitor) 8 hours after wounding. Right: Overall changes in resistance at the eighth hour. D. Left: Cell responses after wounding (control and ERK inhibitor + Kisspeptin-10) during 8 hours after wounding. Right: Overall changes in resistance at the eighth hour. E. Left: Cells responses in different experimental settings, namely control and ERK inhibitor + Kisspeptin-234, over an 8 hours period after wounding. Right: Overall changes in resistance at the eighth hour.