Table 3 Membranous ALCAM expression and clinical and histological tumor characteristics of AA and CAU breast cancer
From: Enhanced down-regulation of ALCAM/CD166 in African-American Breast Cancer
| Membranous ALCAM (n,%) in Caucasian | Membranous ALCAM (n,%) in African American | |||||
|---|---|---|---|---|---|---|
| IRS 0-7 | IRS 8-12 | p value | IRS 0-7 | IRS 8-12 | p value | |
| Age in years | 0.41 | 0.65 | ||||
| ≤50 | 3(3.1) | 26(27.4) | 10(12.8) | 13(16.7) | ||
| >50 | 11(11.6) | 55(57.9) | 27(34.6) | 28(35.9) | ||
| Histological Type | 0.38 | 0.93 | ||||
| IDC | 10(11.4) | 64(72.7) | 36(46.2) | 40(51.3) | ||
| ILC | 0(0) | 7(8) | 1(1.3) | 1(1.3) | ||
| IDC&ILC | 1(1.1) | 6(6.8) | 0(0) | 0(0) | ||
| Histological Grade | 0.02* | 0.04* | ||||
| G1 | 3(3.3) | 26(28.9) | 5(7.2) | 11(15.9) | ||
| G2 | 3(3.3) | 41(45.6) | 11(15.9) | 18(26.1) | ||
| G3 | 6(6.7) | 11(12.2) | 16(23.2) | 8(11.6) | ||
| Tumor size | 0.71 | 0.82 | ||||
| T1 | 9(10) | 60(66.7) | 15(24.6) | 19(31.1) | ||
| T2 | 3(3.3) | 12(13.3) | 9(14.8) | 11(18.0) | ||
| T3-T4 | 1(1.1) | 5(5.5) | 4(6.6) | 3(4.9) | ||
| Lymph node status | 0.95 | 0.44 | ||||
| Negative | 6(8.2) | 42(57.5) | 16(26.2) | 22(36.1) | ||
| Positive | 3(4.1) | 22(30.1) | 12(19.7) | 11(18) | ||
| ER status | 0.0015* | 0.0004* | ||||
| Negative | 7(8.2) | 8(9.4) | 21(28) | 9(12) | ||
| Positive | 6(7.1) | 64(75.3) | 13(17.3) | 32(42.7) | ||
| PR status | 0.034* | 0.002* | ||||
| Negative | 8(8.9) | 20(23.5) | 22(29.3) | 12(16) | ||
| Positive | 5(5.9) | 52(61.2) | 12(16) | 29(38.7) | ||
| HER2-neu status | 0.14 | 0.096 | ||||
| Negative | 12(14) | 55(63.9) | 31(41.9) | 34(45.9) | ||
| Positive | 1(1.2) | 18(20.9) | 2(2.7) | 7(9.5) | ||
| Triple Negative | 0.0006* | 0.0002* | ||||
| Yes | 6(7.1) | 4(4.8) | 19(25) | 6(7.9) | ||
| No | 7(8.3) | 67(79.8) | 16(21.1) | 35(46.1) | ||