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Table 2 Promoter activity of transcriptional regulatory regions in MSCs

From: Mesenchymal stem cells are efficiently transduced with adenoviruses bearing type 35-derived fibers and the transduced cells with the IL-28A gene produces cytotoxicity to lung carcinoma cells co-cultured

Transcriptional regulatory region Luciferase activity (average ± SE)1
(−) 16.8 ± 8.9
SV40 T antigen 100.0 ± 11.5*
Midkine 66.8 ± 27.6*
Survivin 47.5 ± 14.7*
COX-2 368.2 ± 182.8*
CMV 6323.4 ± 2067.3*
  1. 1Relative luciferase activity was calculated based on the SV40 T antigen promoter-mediated activity as 100%. SEs are shown (n = 3).
  2. *P < 0.05, comparing between the COX-2 region and either the SV40 T antigen, the survivin regulatory region, the midkine regulatory region or the CMV promoter.