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Table 1 Growth suppression of OBA-LK1 cells cultured with transduced MSCs

From: Mesenchymal stem cells are efficiently transduced with adenoviruses bearing type 35-derived fibers and the transduced cells with the IL-28A gene produces cytotoxicity to lung carcinoma cells co-cultured

OBA-LK1

MSCs infected with

Mixed cell ratio (OBA-LK1 : MSCs)

PKH 26 positive cells (Percentage ± SE)1

(+)

(−)

 

80.2 ± 2.0

(+)

None

10 : 1

57.4 ± 4.2*

(+)

AdF35-LacZ

10 : 1

65.6 ± 4.1*

(+)

AdF35-IL28A

10 : 1

47.6 ± 2.7*

(+)

None

10 : 3

67.0 ± 4.4#

(+)

AdF35-LacZ

10 : 3

56.1 ± 2.0#

(+)

AdF35-IL-28A

10 : 3

26.4 ± 1.4#

  1. OBA-LK1 cells (3.3 ×104) stained with PKH 26 were cultured with MSCs at a ratio indicated, and all the cells were then stained with Hoechst 33342 on day 4. 1Percentages of PKH 26 positive cells among Hoechst 33342 positive cells and SEs are also shown (n = 3).
  2. *P < 0.05 and #P < 0.01, comparing between cells mixed with AdF35-IL-28A-infected MSCs and cells mixed with uninfected MSCs or AdF35-LacZ-infected MSCs.
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BMC Cancer

ISSN: 1471-2407

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