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Table 6 Effect of MLH1 rs1800734 on radiotherapy acute skin reactions

From: Factors modifying the risk for developing acute skin toxicity after whole-breast intensity modulated radiotherapy

  

Acute G2+ dermatitis

Moist desquamation

  

G0-1 (n = 157)

G2+ (n = 220)

OR

p-value

pBH-value

No (n = 321)

Yes (n = 95)

OR

p-value

pBH-value

MLH1 rs1800734

           

G > A

GG

81 (51.6)

146 (66.4)

   

189 (58.9)

38 (67.9)

   
 

GA

64 (40.8)

60 (27.3)

0.52

0.004

0.029

110 (34.3)

14 (25.0)

0.63

0.172

0.477

 

AA

9 (5.7)

12 (5.5)

0.74

0.514

0.804

17 (5.3)

4 (7.1)

1.17

0.788

0.915

 

Missing

3 (1.9)

2 (0.9)

   

5 (1.6)

0

   

GG vs. GA + AA (dominant)

  

0.55

0.005

0.033

  

0.71

0.257

0.575

GG + GA vs. AA (recessive)

  

0.94

0.889

0.936

  

1.35

0.600

0.860

  1. Abbreviations: MLH1 MutL protein homolog 1, pBH = corrected p-value by Benjamini-Hochberg procedure.
  2. Data are given as no. (%) unless otherwise indicated. P<0.05 is considered significant and is showed in bold.
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BMC Cancer

ISSN: 1471-2407

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