Factors modifying the risk for developing acute skin toxicity after whole-breast intensity modulated radiotherapy

BMC Cancer

Table 4 Multivariate analysis for G2+ dermatitis and moist desquamation

Clinical/genetic factor	Acute G2+ dermatitis		Moist desquamation
	OR	p-value	OR	p-value
Center (CMSE vs. GUH)	-	-	3.206	0.158
BMI	1.088	0.003	1.170	<0.001
Bra cup size (cup ≥ D vs. cup A + B + C)	2.833	0.001	2.146	0.043
Smoking (yes vs. no)	2.711	0.010	-	-
Fractionation (hypo vs. normo)	0.083	<0.001	0.096	<0.001
Treatment position (prone vs. supine)	0.399	0.004	0.373	0.074
Hormone therapy
No	1		1
Concomitant	3.207	0.001	4.770	0.037
Sequential (after IMRT)	1.003	0.994	1.078	0.901
Nodal irradiation (yes vs. no)	1.975	0.100	-	-
Chemotherapy (yes vs. no)	0.954	0.877	-	-
Trastuzumab (yes vs. no)	0.177	<0.001	-	-
*MLH1* rs1800734 G > A
GG	1		-
GA	0.492	0.008	-	-
AA	0.537	0.232	-	-

Abbreviations: GUH Ghent University Hospital, CMSE Clinic Maternity Sainte-Elisabeth, BMI Body Mass Index, MLH1 MutL protein homolog 1.
P<0.05 is considered significant and is showed in bold.

ISSN: 1471-2407