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Table 2 Signaling pathways and associated proteins

From: Proteomic study reveals a functional network of cancer markers in the G1-Stage of the breast cancer cell cycle

Pathway

Representative proteins

MAPK: Proliferation, differentiation, migration

HRAS/RASH, HSP71, HSP7C, HS71L, NF-kappa-β or TF65/RELA, GNAS, PAK1, RAC1, SHC1, MAPK14, GRB2, CRK

ErbB: Proliferation, differentiation, survival, angiogenesis and adhesion/motility/migration/invasion

SHC1, PAK1, GRB2, CRK, HRAS

Cell cycle: Proliferation

SMAD2, SHC1, 1433s/SFNC/stratifin, HDAC1/2, CREBBP, CUL1, CDC2

DNA damage repair: Maintenance of genome integrity

PARP1, TP53BP, PCNA, PRKDC, DDB2, CREBBP (Table 1)

Apoptosis: Cell death

BCLF1, BAX, TF65, IASPP

p53: Cell cycle arrest, apoptosis, senescence, inhibition of angiogenesis/metastasis, inhibition of IGF-1/mTOR pathway

BAX, RIR2B, DDB2, CDC2, 1433s

TGF-β: proliferation, apoptosis, differentiation, migration

SMAD2, CREBBP, CUL1, RHOA

NF-kappa-B: Regulation of genes involved in immunity, inflammation, cell survival

NF-kappa-β/TF65/RELA

Wnt: Cell division, development, adhesion

CTNB1, SMAD2, CTBP2, CREBBP, CUL1, RAC1

Jak/STAT: Growth, proliferation, development, cell fate, immunity, cell cycle, apoptosis

STAT 3, PTN11, STAT1, GRB2, CREBBP

Toll-like: Innate immune responses to pathogenic bacteria

TLR2, IRF3, TF65, MAPK14, STAT1, RAC1

Notch: Proliferative signaling, angiogenesis

HDAC1, CTBP1/2, CREBBP

VEGF: Angiogenesis

MAPK14, SHC1, RAC1, HRAS

Adhesion/integrin signaling: Cell migration, tissue invasion

CTNB1, PAK1, GRB2, CRK, HRAS, RAC1, PP1A/B, CDC2, RHOA, ILK, MUC1, PTN11

Ca signaling: Proliferation, apoptosis, metabolism

AT2A2, GNAS1

Insulin signaling: Maintenance of energy metabolism/homeostasis

Q96RG5, TFR1, PTN11, COA1, SHC1, GRB2, CRK, PP1A/B

Chemokine: Immune response, cell growth, differentiation, survival, migration, apoptosis, regulation of cytoskeleton

STAT3, PAK1, TF65, SHC1, GRB2, CRK, STAT1, RHOA, RAC1, HRAS

PPAR signaling: Lipid metabolism, adipocyte differentiation

PPARG, ILK

Fatty acid biosynthesis

COA1