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Table 2 Drug concentrations used in cytotoxicity assay

From: Characterization and drug sensitivity profiling of primary malignant mesothelioma cells from pleural effusions

   

Drug concentrations (μg/ml)

Alkylating Agents

Nitrogen mustard

Chlorambucil

83.3

 

Aziridine

Mitomycin C

0.3 - 0.6

 

Tetrazine

Dacarbazine

16.7

Platinum drugs

 

Cisplatin

0.2

  

Carboplatin

1.7 - 8.3

  

Oxaliplatin

4.2

Antimetabolites

Pyrimidine analogues

Fluorouracil

41.7

  

Cytarabine

8.3 - 16.7

  

Gemcitabine

33.3

 

Purine analogues

Mercaptopurine

46.3 - 69.4

  

Fludarabine

20.8 - 41.7

  

Cladribine

0.8

 

Antifolates

Methotrexate

4.2 - 20.8

  

Pemetrexed

20.8

 

Other

Hydroxyurea

41.7

Antimicrotubule agents

Taxanes

Paclitaxel

3.3

  

Docetaxel

8.3 - 16.7

 

Vinca alkaloids

Vinblastine

0.2 - 8.3

  

Vincristine

0.2 - 0.8

  

Vinorelbine

1.7 - 8.3

Topoisomerase inhibitors

Type I

Topotecan

0.2 -1.7

  

Irinotecan

16.7

 

Type II

Etoposide

16.7

  

Amsacrine

4.2

Proteasome inhibitor

 

Bortezomib

0.2 - 2.9

Multifunctional drugs

Anthracycline

Daunorubicin

4.2 - 16.7

  

Doxorubicin

0.8 - 1.7

  

Epirubicin

1.7

 

Other

Actinomycin D

0.1 - 0.4

  

Bleomycin

2.5 - 12.5*

Enzyme

 

Asparaginase

0.6 - 8.3*

Corticosteroid

 

Prednisolone

16.7 - 41.7

  1. Drugs are divided according to their mechanism of action. * = IU/ml.
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BMC Cancer

ISSN: 1471-2407

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