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Table 2 Drug concentrations used in cytotoxicity assay

From: Characterization and drug sensitivity profiling of primary malignant mesothelioma cells from pleural effusions

    Drug concentrations (μg/ml)
Alkylating Agents Nitrogen mustard Chlorambucil 83.3
  Aziridine Mitomycin C 0.3 - 0.6
  Tetrazine Dacarbazine 16.7
Platinum drugs   Cisplatin 0.2
   Carboplatin 1.7 - 8.3
   Oxaliplatin 4.2
Antimetabolites Pyrimidine analogues Fluorouracil 41.7
   Cytarabine 8.3 - 16.7
   Gemcitabine 33.3
  Purine analogues Mercaptopurine 46.3 - 69.4
   Fludarabine 20.8 - 41.7
   Cladribine 0.8
  Antifolates Methotrexate 4.2 - 20.8
   Pemetrexed 20.8
  Other Hydroxyurea 41.7
Antimicrotubule agents Taxanes Paclitaxel 3.3
   Docetaxel 8.3 - 16.7
  Vinca alkaloids Vinblastine 0.2 - 8.3
   Vincristine 0.2 - 0.8
   Vinorelbine 1.7 - 8.3
Topoisomerase inhibitors Type I Topotecan 0.2 -1.7
   Irinotecan 16.7
  Type II Etoposide 16.7
   Amsacrine 4.2
Proteasome inhibitor   Bortezomib 0.2 - 2.9
Multifunctional drugs Anthracycline Daunorubicin 4.2 - 16.7
   Doxorubicin 0.8 - 1.7
   Epirubicin 1.7
  Other Actinomycin D 0.1 - 0.4
   Bleomycin 2.5 - 12.5*
Enzyme   Asparaginase 0.6 - 8.3*
Corticosteroid   Prednisolone 16.7 - 41.7
  1. Drugs are divided according to their mechanism of action. * = IU/ml.