Table 4 Emergent network clusters in Tumors
From: Large differences in global transcriptional regulatory programs of normal and tumor colon cells
Tumor cluster* | Number of genes | Pathway | Adjusted P-value$ |
|---|---|---|---|
1 | 120 | Vascular smooth muscle contraction | 1.1e-09 |
2 | 112 | GnRH signaling pathway | 5.9e-04 |
2 | 112 | Staphylococcus aureus infection | 4.8e-02 |
3 | 70 | Chemokine signaling pathway | 8.1e-08 |
3 | 70 | Toll-like receptor signaling pathway | 3.1e-07 |
3 | 70 | Ether lipid metabolism | 9.5e-04 |
4 | 51 | Glycosphingolipid biosynthesis - ganglio series | 1.6e-03 |
4 | 51 | Wnt signaling pathway | 1.7e-03 |
4 | 51 | GnRH signaling pathway | 1.3e-02 |
5 | 70 | Adherens junction | 1.9e-04 |
5 | 70 | Chemokine signaling pathway | 4.1e-02 |
7 | 44 | Tight junction | 5.6e-05 |
7 | 44 | Tryptophan metabolism | 2.4e-04 |
7 | 44 | Glycosaminoglycan biosynthesis - chondroitin sulfate | 4.7e-04 |
8 | 27 | Adherens junction | 4.0e-03 |
9 | 16 | Protein digestion and absorption | 4.4e-07 |
9 | 16 | Adherens junction | 5.9e-03 |
11 | 16 | MAPK signaling pathway | 2.1e-15 |
11 | 16 | Prion diseases | 2.4e-03 |
13 | 24 | Beta-Alanine metabolism | 4.4e-04 |
13 | 24 | NOD-like receptor signaling pathway | 9.8e-03 |
16 | 32 | Glycosaminoglycan biosynthesis - chondroitin sulfate | 4.5e-08 |
18 | 14 | Apoptosis | 2.2e-06 |
18 | 14 | Nucleotide excision repair | 1.0e-03 |
19 | 14 | Cytokine-cytokine receptor interaction | 1.4e-02 |
21 | 13 | Butanoate metabolism | 5.6e-05 |
21 | 13 | Amino sugar and nucleotide sugar metabolism | 3.4e-03 |
22 | 12 | Glutathione metabolism | 3.4e-04 |
23 | 18 | DNA replication | 6.7e-06 |
25 | 32 | Vascular smooth muscle contraction | 3.7e-06 |
28 | 12 | DNA replication | 9.6e-05 |