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Table 3 In-silico network validation

From: Large differences in global transcriptional regulatory programs of normal and tumor colon cells

Transcription factor (Gene Symbol)

# Targets (In normal network)

# Peaks (In hmChIP DB)

Enrichment ratio

p-value

FDR

TCF4

408

46,018

1.82

2.0e-07

3.7e-06

NR3C1

246

24,967

0.60

0.12

-

PBX3

186

39,691

0.40

0.0063

0.019

HNF4A

103

32,083

2.71

0.00027

0.0016

TCF12

67

54,191

3.33

2.0e-06

1.8e-05

RBL2

55

16,395

2.33

0.0050

0.018

SUZ12

50

8,742

0.62

0.12

-

ESRRA

42

3,284

1.50

0.37

-

FOXP2

42

44,482

2.00

0.043

0.11

MAX

41

16,467

1.80

0.12

-

CDX2

40

24,460

1.38

0.38

-

SRF

39

35,784

1.91

0.052

0.12

STAT1

35

2,804

3.20

0.00097

0.0044

FOXA1

32

21,540

0.55

0.062

0.12

NFYB

31

4,630

1.20

1

-

RAD21

26

33,302

1.40

0.50

-

  1. Results provided by hmChIP tool containing ChIP-Seq and ChIP-chip ENCODE experiments [33]. TFs are ordered according to the number of target genes in the normal network. Cells with enrichment ratio in bold highlight significantly overrepresented TFs.
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BMC Cancer

ISSN: 1471-2407

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