Large differences in global transcriptional regulatory programs of normal and tumor colon cells

BMC Cancer

Table 2 Nodes with increased activity

TFs that most increase their activity in tumors
Transcription factor	Targets in Normal network	Targets in Tumor network	Gained interactions	Ratio T/N
SNAI2	1	119	118	119.0
MMP14	10	121	111	12.1
AEBP1	103	186	83	1.8
BASP1	43	123	80	2.9
HCLS1	91	170	79	1.9
TFEC	6	84	78	14.0
DKK3	41	112	71	2.7
COL1A1	62	131	69	2.1
CD86	74	141	67	1.9
MAFB	125	189	64	1.5
NOTCH3	18	82	64	4.6
GLI2	37	100	63	2.7
TGFB1	1	61	60	61
GREM1	14	70	56	5.0
HOPX	46	102	56	2.2
*Most up-regulated targets in Tumors*
Target gene	Targets in-degree in Normal	Targets in-degree in Tumor	Gained interactions	Ratio T/N
NNMT	3	32	29	10.7
CDH11	1	24	23	24.0
RAB31	20	42	22	2.1
MXRA8	3	23	20	7.7
RFTN1	8	28	20	3.5
CFH	3	20	17	6.7
COL3A1	14	31	17	2.2
EMILIN1	12	28	16	2.3
ENTPD1	12	28	16	2.3
MRC2	7	23	16	3.3
STAU1	1	17	16	17.0
AXL	9	24	15	2.7
OLFML2B	10	25	15	2.5
VCAM1	1	15	14	15.0
COL6A3	12	25	13	2.1

The table lists the top 15 TFs and target genes that most increase their activity in the tumor network, sorted by the number of gained interactions. Only nodes that appeared in both networks were considered. See complete lists in Additional file 3.

ISSN: 1471-2407