From: Large differences in global transcriptional regulatory programs of normal and tumor colon cells
TFs that most increase their activity in tumors | ||||
---|---|---|---|---|
Transcription factor | Targets in Normal network | Targets in Tumor network | Gained interactions | Ratio T/N |
SNAI2 | 1 | 119 | 118 | 119.0 |
MMP14 | 10 | 121 | 111 | 12.1 |
AEBP1 | 103 | 186 | 83 | 1.8 |
BASP1 | 43 | 123 | 80 | 2.9 |
HCLS1 | 91 | 170 | 79 | 1.9 |
TFEC | 6 | 84 | 78 | 14.0 |
DKK3 | 41 | 112 | 71 | 2.7 |
COL1A1 | 62 | 131 | 69 | 2.1 |
CD86 | 74 | 141 | 67 | 1.9 |
MAFB | 125 | 189 | 64 | 1.5 |
NOTCH3 | 18 | 82 | 64 | 4.6 |
GLI2 | 37 | 100 | 63 | 2.7 |
TGFB1 | 1 | 61 | 60 | 61 |
GREM1 | 14 | 70 | 56 | 5.0 |
HOPX | 46 | 102 | 56 | 2.2 |
Most up-regulated targets in Tumors | ||||
Target gene | Targets in-degree in Normal | Targets in-degree in Tumor | Gained interactions | Ratio T/N |
NNMT | 3 | 32 | 29 | 10.7 |
CDH11 | 1 | 24 | 23 | 24.0 |
RAB31 | 20 | 42 | 22 | 2.1 |
MXRA8 | 3 | 23 | 20 | 7.7 |
RFTN1 | 8 | 28 | 20 | 3.5 |
CFH | 3 | 20 | 17 | 6.7 |
COL3A1 | 14 | 31 | 17 | 2.2 |
EMILIN1 | 12 | 28 | 16 | 2.3 |
ENTPD1 | 12 | 28 | 16 | 2.3 |
MRC2 | 7 | 23 | 16 | 3.3 |
STAU1 | 1 | 17 | 16 | 17.0 |
AXL | 9 | 24 | 15 | 2.7 |
OLFML2B | 10 | 25 | 15 | 2.5 |
VCAM1 | 1 | 15 | 14 | 15.0 |
COL6A3 | 12 | 25 | 13 | 2.1 |