Figure 1

PI4KA transcript abundance in human liver samples of various subtypes. Scatter plots show the PI4KA mRNA levels in human liver tissues as assayed by RT-real time PCR. Values represent the gene expression of each sample relative to the mean value for two control samples from normal hepatic tissues. The 18S RNA levels were used for normalization. Means with standard deviations are indicated for each sample category. P values from Kruskal-Wallis tests (more than two groups, panels A and B; black line) or Mann–Whitney U-tests (two groups, panel C; black line with arrows) are indicated. (A) Comparison between normal hepatic tissue (n = 5), cirrhotic tissue (n = 21), and benign (HCA, n = 101) and malignant (HCC, n = 217) hepatocellular tumors. (B) Expression in different hepatocellular adenoma (HCA) groups subdivided into adenomas inactivated for HNF1A (n = 27), inflammatory adenomas (n = 44), β-catenin-activated adenomas (n = 10), inflammatory and β-catenin-activated adenomas (n = 13) and unclassified adenomas (n = 7). (C) Expression compared according to the differentiation grade of HCC grouped according to the Edmonson classification (Grades I-II, n = 118; Grades III-IV, n = 88).