Variable | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
Hazard ratio 95% CI P | ||||
Overall survival | ||||
Ang-2 | <0.001 | ns | ||
VEGF | 0.002 | ns | ||
sVEGFR-2 | 0.001 | ns | ||
VEGF/sVEGFR-2 | <0.001 | ns | ||
Ang-2/VEGF | 0.005 | ns | ||
Ang-2/sVEGFR-2 | 0.002 | ns | ||
Ascites | 0.005 | ns | ||
Stage | 0.005 | ns | ||
Primary residual tumor | <0.001 | 0.004 | ||
None | ||||
< 1 cm | <0.001 | 6.38 | 1.61-25.225 | 0.008 |
>1 cm | <0.001 | 8.10 | 2.346-27.814 | 0.001 |
Chemotherapy response | <0.001 | <0.001 | ||
Complete response | ||||
Partial response | <0.001 | 5.192 | 1.488-18.113 | 0.010 |
Stable disease | <0.001 | 44.71 | 6.008-332.56 | <0.001 |
Progressive disease | <0.001 | 16.80 | 4.238-66.522 | <0.001 |
Recurrence free survival | ||||
Ang-2 | 0.001 | ns | ||
VEGF | 0.019 | ns | ||
sVEGFR-2 | 0.031 | ns | ||
VEGFR/sVEGFR-2 | <0.001 | ns | ||
Ang-2/VEGF | 0.022 | ns | ||
Ang-2/sVEGFR-2 | <0.001 | ns | ||
Ascites | 0.001 | ns | ||
Histological grade | 0.001 | ns | ||
Stage | <0.001 | ns | ||
Primary residual tumor | <0.001 | <0.001 | ||
None | ||||
< 1 cm | <0.001 | 6.81 | 2.112-21.961 | 0.001 |
>1 cm | <0.001 | 7.87 | 2.926-21.163 | <0.001 |
Chemotherapy response | 0.012 | ns | ||
Complete response | ||||
Partial response | 0.007 | |||
Stable disease | 0.158 (n = 1) |