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Table 3 Univariate and multivariate analysis of overall survival and recurrence free survival

From: Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer

Variable Univariate analysis Multivariate analysis
Hazard ratio 95% CI P
Overall survival     
Ang-2 <0.001    ns
VEGF 0.002    ns
sVEGFR-2 0.001    ns
VEGF/sVEGFR-2 <0.001    ns
Ang-2/VEGF 0.005    ns
Ang-2/sVEGFR-2 0.002    ns
Ascites 0.005    ns
Stage 0.005    ns
Primary residual tumor <0.001    0.004
None     
< 1 cm <0.001 6.38 1.61-25.225 0.008
>1 cm <0.001 8.10 2.346-27.814 0.001
Chemotherapy response <0.001    <0.001
Complete response     
Partial response <0.001 5.192 1.488-18.113 0.010
Stable disease <0.001 44.71 6.008-332.56 <0.001
Progressive disease <0.001 16.80 4.238-66.522 <0.001
Recurrence free survival     
Ang-2 0.001    ns
VEGF 0.019    ns
sVEGFR-2 0.031    ns
VEGFR/sVEGFR-2 <0.001    ns
Ang-2/VEGF 0.022    ns
Ang-2/sVEGFR-2 <0.001    ns
Ascites 0.001    ns
Histological grade 0.001    ns
Stage <0.001    ns
Primary residual tumor <0.001    <0.001
None     
< 1 cm <0.001 6.81 2.112-21.961 0.001
>1 cm <0.001 7.87 2.926-21.163 <0.001
Chemotherapy response 0.012    ns
Complete response     
Partial response 0.007    
Stable disease 0.158 (n = 1)    
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BMC Cancer

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