Circulating levels of angiogenesis biomarkers in different subgroups of patients. Levels of Ang-2 (A), VEGF (B), VEGF/sVEGFR-2 (D) and Ang-2/ sVEGFR-2 (F) ratios were elevated whereas sVEGFR-2 (C) was lower in patients with ovarian carcinoma than in women with normal ovaries, benign and/or borderline ovarian neoplasms. There were no differences in serum levels of Ang-2/VEGF ratio between patients with normal ovaries compared to patients with ovarian neoplasms (E). AUC values of CA 125, Ang-2/sVEGFR-2 ratio, Ang-2 and VEGF were significant in differentiating ovarian carcinoma from benign or borderline ovarian tumors (G). When combining CA125 with Ang-2/sVEGFR-2 ratio the AUC value was similar to CA 125 alone when including borderline tumors and ovarian carcinoma (H).