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Table 1 Binding affinity of Jac-A and (-)-gossypol with Bcl-x L , Bcl-2 or Mcl-1 determined by a fluorescence polarisation assay (Ki, μM)

From: Jacarelhyperol A induced apoptosis in leukaemia cancer cell through inhibition the activity of Bcl-2 proteins

Compound Bcl-xL Bcl-2 Mcl-1
Jac-A 0.46 0.43 1.69
(-)-Gossypol 1.01 0.95 0.86