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Table 5 Association of CSC markers with clincopathologic features in the NACRT group

From: Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy

   EpCAM (+)   CD24 (+)   CD44 (+)   CD133 (+)   CXCR4 (+)   ALDH1 (+)  
Parameter Total (n = 10) p (n = 6) p (n = 14) p (n = 5) p (n = 8) p (n = 11) p
Histological classification
Grade 1/2 11 8 0.186 4 0.547 9 1.000 4 0.0801 3 0.0633 8 0.547
Grade 3 5 2   1   4   0   4   3  
ungradeable 1 0   1   1   1   1   0  
ypT  
  ypT2 1 1 1.000 0 1.000 1 1.000 0 1.000 0 1.000 1 1.000
  ypT3 16 9   6 13    5   8   10  
ypN  
  ypN1 4 3 0.603 2 0.584 3 1.000 2 0.538 2 1.000 3 1.000
  ypN0 13 7   4   11   3   6   8  
Tumour down stage  
  Present 5 4 0.338 2 1.000 5 0.515 1 1.000 4 0.131 3 1.000
  Absent 12 6   4   9   4   4   8  
Lymphatic invasion  
  Present 1 0 1.000 0 1.000 1 1.000 0 1.000 0 1.000 1 1.000
  Absent 16 10   6   13   5   8   10  
Blood vessel invasion  
  Present 11 7 0.644 3 0.600 9 1.000 3 1.000 4 0.335 7 1.000
  Absent 6 3   3   5   2   4   4  
Perineural invasion  
  Present 12 6 0.338 3 0.280 10 1.000 3 0.600 6 1.000 8 1.000
  Absent 5 4   3   4   2   2   3  
Recurrence  
  Present 11 6 1.000 5 0.333 10 0.515 4 0.600 7 0.131 7 1.000
  Absent 6 4   1   4   1   1   4  
Liver metastasis  
  Present 7 3 0.350 3 0.644 6 1.000 2 1.000 6 0.0152 6 0.304
  Absent 10 7   3   8   3   2   5  
Tumor destruction (Evans’s criteria)  
  I/lla 8 5 1.000 1 0.131 7 1.000 1 0.294 3 0.637 5 1.000
  llb/lll 9 5   5   7   4   5   6  
  1. Fisher’s exact test.
  2. The bold value indicates a statistically significant result.