Table 5 Association of CSC markers with clincopathologic features in the NACRT group
| Â | Â | EpCAM (+) | Â | CD24 (+) | Â | CD44 (+) | Â | CD133 (+) | Â | CXCR4 (+) | Â | ALDH1 (+) | Â |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameter | Total | (n = 10) | p | (n = 6) | p | (n = 14) | p | (n = 5) | p | (n = 8) | p | (n = 11) | p |
Histological classification | |||||||||||||
Grade 1/2 | 11 | 8 | 0.186 | 4 | 0.547 | 9 | 1.000 | 4 | 0.0801 | 3 | 0.0633 | 8 | 0.547 |
Grade 3 | 5 | 2 | Â | 1 | Â | 4 | Â | 0 | Â | 4 | Â | 3 | Â |
ungradeable | 1 | 0 | Â | 1 | Â | 1 | Â | 1 | Â | 1 | Â | 0 | Â |
ypT | Â | ||||||||||||
  ypT2 | 1 | 1 | 1.000 | 0 | 1.000 | 1 | 1.000 | 0 | 1.000 | 0 | 1.000 | 1 | 1.000 |
  ypT3 | 16 | 9 |  | 6 | 13 |  |  | 5 |  | 8 |  | 10 |  |
ypN | Â | ||||||||||||
  ypN1 | 4 | 3 | 0.603 | 2 | 0.584 | 3 | 1.000 | 2 | 0.538 | 2 | 1.000 | 3 | 1.000 |
  ypN0 | 13 | 7 |  | 4 |  | 11 |  | 3 |  | 6 |  | 8 |  |
Tumour down stage | Â | ||||||||||||
  Present | 5 | 4 | 0.338 | 2 | 1.000 | 5 | 0.515 | 1 | 1.000 | 4 | 0.131 | 3 | 1.000 |
  Absent | 12 | 6 |  | 4 |  | 9 |  | 4 |  | 4 |  | 8 |  |
Lymphatic invasion | Â | ||||||||||||
  Present | 1 | 0 | 1.000 | 0 | 1.000 | 1 | 1.000 | 0 | 1.000 | 0 | 1.000 | 1 | 1.000 |
  Absent | 16 | 10 |  | 6 |  | 13 |  | 5 |  | 8 |  | 10 |  |
Blood vessel invasion | Â | ||||||||||||
  Present | 11 | 7 | 0.644 | 3 | 0.600 | 9 | 1.000 | 3 | 1.000 | 4 | 0.335 | 7 | 1.000 |
  Absent | 6 | 3 |  | 3 |  | 5 |  | 2 |  | 4 |  | 4 |  |
Perineural invasion | Â | ||||||||||||
  Present | 12 | 6 | 0.338 | 3 | 0.280 | 10 | 1.000 | 3 | 0.600 | 6 | 1.000 | 8 | 1.000 |
  Absent | 5 | 4 |  | 3 |  | 4 |  | 2 |  | 2 |  | 3 |  |
Recurrence | Â | ||||||||||||
  Present | 11 | 6 | 1.000 | 5 | 0.333 | 10 | 0.515 | 4 | 0.600 | 7 | 0.131 | 7 | 1.000 |
  Absent | 6 | 4 |  | 1 |  | 4 |  | 1 |  | 1 |  | 4 |  |
Liver metastasis | Â | ||||||||||||
  Present | 7 | 3 | 0.350 | 3 | 0.644 | 6 | 1.000 | 2 | 1.000 | 6 | 0.0152 | 6 | 0.304 |
  Absent | 10 | 7 |  | 3 |  | 8 |  | 3 |  | 2 |  | 5 |  |
Tumor destruction (Evans’s criteria) |  | ||||||||||||
  I/lla | 8 | 5 | 1.000 | 1 | 0.131 | 7 | 1.000 | 1 | 0.294 | 3 | 0.637 | 5 | 1.000 |
  llb/lll | 9 | 5 |  | 5 |  | 7 |  | 4 |  | 5 |  | 6 |  |