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Figure 1 | BMC Cancer

Figure 1

From: Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)

Figure 1

The complexity of KIT WT / PDGFRA WT GIST molecular biology. KIT WT/PDGFRA WT GIST could be firstly divided two main group according to the SDHB immunohistochemical status: SDHB IHC+ (including NF1-mutated GIST and sporadic KIT WT/PDGFRA WT GIST with or without KRAS/BRAF mutations) and SDHB IHC- or SDH-deficient GIST. The latter could be further divided according to the SDHA immunohistochemical status: SDHB IHC-/SDHA IHC- GIST (pediatric type or young adult GIST characterized by germline or somatic inactivating SDHA mutations) and SDHB IHC/SDHA IHC+ GIST (including Carney-Stratakis Syndrome-related GIST, characterized by germline or somatic inactivating SDHB, −C, −D mutations, Carney Triad-related GIST that lack SDHx mutations, and sporadic KIT WT/PDGFRA WT GIST, characterized by germline or somatic inactivating SDHB, −C, −D mutations and SDHA mutations, reported in only three cases [15]. In red the subset of KIT WT/PDGFRA WT GIST referred to as quadruple WT GIST (KIT WT/PDGFRA WT/SDH WT/RAS-P WT), that represent the subject of this study.

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