Tongue carcinoma infrequently harbor common actionable genetic alterations

BMC Cancer

Table 3 Specific mutations and clinic-pathologic features samples where mutations were detected (n = 20)

Sample	Gene	Mutation	TNM	Overall stage	Age/sex	Smoking status	Adjuvant treatment	Outcome	Time to recurrence (Months)
Tumors with a single mutation
2000294	MET	N375S	TxN2bM1	4	53/M	Ever	Yes	Recurrence	7
20021078	STK11	F354L	T4aN1M0	4	79/M	Ever	Yes	No Recurrence	N.A.
21789206	PIK3CA	E542K	T4aN0M0	4	54/M	Ever	Yes	Recurrence	33
22873606	TP53	R175H	T4aN0M0	4	75/M	Ever	No	Unknown	N.A.
27197906	PIK3CA	H1047R	T4aN0M0	4	56/M	Ever	Yes	Unknown	N.A.
NPC7*	MET	N375S	T4N2bM0	4	22/F	Ever	Yes	Recurrence	6
TM24*	TP53	R282W	T2N2bM0	4	60/M	Ever	Yes	Recurrence	15
TM47*	MET	N375S	T4aN2cM0	4	76/M	Ever	Yes	Recurrence	6
93488640	NRF2	G31A	T2N1M0	3	61/M	Never	Yes	Recurrence	31
51236487	TP53	R273P	T2N0M0	2	60/M	Never	Yes	Unknown	N.A.
84033237	TP53	R273C	T4aN2bM0	4	56/M	Never	No	Recurrence	24
980003	STK11	F354L	T2N0M0	2	39/M	Never	No	Unknown	N.A.
YT3**	MET	N375S	T3N0M0	3	52/F	Never	No	Unknown	N.A.
YT4	BRAF	D594G	T1N0M0	1	42/F	Never	No	No Recurrence	N.A.
990386	TP53	R175H	T4aN0M0	4	63/M	Unknown	Unknown	No Recurrence	N.A.
2000665	MET	N375S	T4aN2bM0	4	53/F	Unknown	Yes	No Recurrence	N.A.
Tumors with two separate mutations
980398	MET	N375S	T2N1M0	3	61/M	Never	No	No Recurrence	N.A.
980398	TP53	G245S	T2N1M0	3	61/M	Never	No	No Recurrence	N.A.
1784450	MET	N375S	T4aN2cM0	4	66/M	Ever	No	Recurrence	5
1784450	STK11	F354L	T4aN2cM0	4	66/M	Ever	No	Recurrence	5
20020797	STK11	F354L	T4aN2cM0	4	69/M	Ever	Yes	No Recurrence	N.A.
20020797	TP53	Y163C	T4aN2cM0	4	69/M	Ever	Yes	No Recurrence	N.A.
TM44***	PIK3CA	H1047L	T2N2bM0	4	62/M	Ever	Yes	No Recurrence	N.A.
TM44***	STK11	F354L	T2N2bM0	4	62/M	Ever	Yes	No Recurrence	N.A.

*Successfully propagated as cell line.
**Refused conventional treatment and lost to follow-up.
***Successfully propagated as cell line, patient had a 30-day mortality after primary surgery.

ISSN: 1471-2407