Table 1 LungCarta 1.0- lung panel gene targets

AKT1

E17K

MET

N375S, 982_1028del47

ALK

C1156Y, L1196M

NOTCH1

H2276fs*79, D1643H, R2328W, T1997M, V1672I, V2444fs*35

BRAF

D594G/M, G469S/E/A/V, L597Q/V, V600E/K/M

NRAS

Q61E/K/H/L/R/P

DDR2

C580Y, D125Y, G253C, G505S, G774E/V, I120M, I638F, L239R, L63V, T765P

NRF2

D29H, D77N/A, E79Q/K/G, G31A, G81D, R34Q,

EGFR

R108K, T263P, A289V, G598V, E709K/H, E709A/G/V, G719S/C/A/D, G719S/C/A/D, M766_A767insAI, D761Y/N, S768I, R776C/M, V769_D770insASV, V769_D770insCV, D770_N771 > AGG/V769_D770insASV/V769_D770insASV, D770_N771insG, N771_P772 > SVDNR, P772_H773insV, H773 > NPY, H773_V774insNPH/PH/H, V774_C775insHV, T790M, L858R/M, L861Q, E746_T751del, E746_A750del, E746_T751del, E746_T751del, S752D, L747_E749del, L747_T750del, L747_S752del, L747_T751del, L747_S752del, P753S, A750P, T751A, T751P, T751I, S752I/F, S752_I759del, L747_Q ins, E746_T751del, I ins (combined), E746_A750del, T751A (combined), L747_E749del, A750P (combined), L747_T750del, P ins (combined), L747_S752del, Q ins (combined), T854A

NTRK1

Q80*, R119H, S326R

EPHA3

A435S, D446Y, S449F, D806N, G187R, G518L, K761N, G766E, M269I, N379K, N85S, S229Y, T166N, T37K, T393K, W250R

NTRK2

Q666R, C45F, G261R, L138F, L670M, L755L

EPHA5

D493Y, G582E, M1034I, N1032S, R1007Q, S566Y, S810I, T856I

NTRK3

I769N, L152I, L248M, L270M, L336Q, S184C, T283K, V307L, R271F

ERBB2

M774_A775insAYVM, A775_G776insAYVM

PIK3CA

E542Q/K, E545Q/K. H1047Y/R/L

FGFR4

P672T, H192fs*19

PTCH1

R1308G, R682L, S1326fs*46

JAK2

L609S, P503L, R1122P, Y931C

PTEN

R233*

KRAS

G12S/V/F/R/A/C/D, G13C/S/A/V/DQ61L/R/P/H/E/K

PTPN11

E76V

MAP2K1

D67N, K57N, Q56P

PTPRD

D1162N, D154Y, I44I, L1036Q, P1809R, R1536L, R584S, S1703R, T337A, V483E

STK11

A347fs*13, A43_L50del6, D327fs*10, E120*, E165*, E223*, E70*, E70fs*26, F354L, G163C, G188fs*99, G196V, G56fs*4, G56W, G91L, H174R, I26fs*25, K191*, K78E, L285Q, L50_D53del4, M51fs*14, P179L, Q123R, Q137*, Q159*, Q170*, Q220*, Q37L, R426W, R86G, V197fs*69, V236fs*30, Y272Y

TP53

G245C/S, G245D/V, R158C/G/L/P, R175L/H, R248L/Q/R/W, R249S/W/M, R273C/H/L/P, R282G/W, V157F, Y163C,R175L/H Y220C