Skip to main content

Table 1 LungCarta 1.0- lung panel gene targets

From: Tongue carcinoma infrequently harbor common actionable genetic alterations

Gene Mutation Gene Mutation
AKT1 E17K MET N375S, 982_1028del47
ALK C1156Y, L1196M NOTCH1 H2276fs*79, D1643H, R2328W, T1997M, V1672I, V2444fs*35
BRAF D594G/M, G469S/E/A/V, L597Q/V, V600E/K/M NRAS Q61E/K/H/L/R/P
DDR2 C580Y, D125Y, G253C, G505S, G774E/V, I120M, I638F, L239R, L63V, T765P NRF2 D29H, D77N/A, E79Q/K/G, G31A, G81D, R34Q,
EGFR R108K, T263P, A289V, G598V, E709K/H, E709A/G/V, G719S/C/A/D, G719S/C/A/D, M766_A767insAI, D761Y/N, S768I, R776C/M, V769_D770insASV, V769_D770insCV, D770_N771 > AGG/V769_D770insASV/V769_D770insASV, D770_N771insG, N771_P772 > SVDNR, P772_H773insV, H773 > NPY, H773_V774insNPH/PH/H, V774_C775insHV, T790M, L858R/M, L861Q, E746_T751del, E746_A750del, E746_T751del, E746_T751del, S752D, L747_E749del, L747_T750del, L747_S752del, L747_T751del, L747_S752del, P753S, A750P, T751A, T751P, T751I, S752I/F, S752_I759del, L747_Q ins, E746_T751del, I ins (combined), E746_A750del, T751A (combined), L747_E749del, A750P (combined), L747_T750del, P ins (combined), L747_S752del, Q ins (combined), T854A NTRK1 Q80*, R119H, S326R
EPHA3 A435S, D446Y, S449F, D806N, G187R, G518L, K761N, G766E, M269I, N379K, N85S, S229Y, T166N, T37K, T393K, W250R NTRK2 Q666R, C45F, G261R, L138F, L670M, L755L
EPHA5 D493Y, G582E, M1034I, N1032S, R1007Q, S566Y, S810I, T856I NTRK3 I769N, L152I, L248M, L270M, L336Q, S184C, T283K, V307L, R271F
ERBB2 M774_A775insAYVM, A775_G776insAYVM PIK3CA E542Q/K, E545Q/K. H1047Y/R/L
FGFR4 P672T, H192fs*19 PTCH1 R1308G, R682L, S1326fs*46
JAK2 L609S, P503L, R1122P, Y931C PTEN R233*
KRAS G12S/V/F/R/A/C/D, G13C/S/A/V/DQ61L/R/P/H/E/K PTPN11 E76V
MAP2K1 D67N, K57N, Q56P PTPRD D1162N, D154Y, I44I, L1036Q, P1809R, R1536L, R584S, S1703R, T337A, V483E
STK11 A347fs*13, A43_L50del6, D327fs*10, E120*, E165*, E223*, E70*, E70fs*26, F354L, G163C, G188fs*99, G196V, G56fs*4, G56W, G91L, H174R, I26fs*25, K191*, K78E, L285Q, L50_D53del4, M51fs*14, P179L, Q123R, Q137*, Q159*, Q170*, Q220*, Q37L, R426W, R86G, V197fs*69, V236fs*30, Y272Y TP53 G245C/S, G245D/V, R158C/G/L/P, R175L/H, R248L/Q/R/W, R249S/W/M, R273C/H/L/P, R282G/W, V157F, Y163C,R175L/H Y220C
  1. *Frameshift or truncating mutation.