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Table 1 Summary of relevant data for cells treated with S-NPAA

From: In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cells

Cell line OPH activity level* GSH depletion with S-NPAA Intrinsic oxidative stress** Apoptosis with S-NPAA Cell viability with S-NPAA
RWPE-1 + + + + +
LNCaP ++ +++ ++ ++ +++
DU145 + + ++++ ++ +++
PC3 + + +++++ ++ +++
COS-7 + + NR + +
COS-7-OPH +++++ +++++ NR ++ ++
  1. The number of + symbols indicates the fold increase of the observed condition compared to non-tumorigenic RWPE-1, e.g., COS-7-OPH cells have about five-fold more OPH activity than RWPE-1 cells. NR indicates that the condition has never been reported.
  2. *From McGoldrick et al., [24].
  3. **Intrinsic oxidative stress levels are summarized from Kumar et al., [3].