From: PIN3 duplication may be partially responsible for TP53haploinsufficiency
Number of sample | Diagnosis | TP53mutations | PIN3 | Codon 72 (DNA) | Codon 72 (cDNA) | Subcloning results | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Type | cDNA | DNA | Colonies | PIN3 | Codon 72 | Conclusions | |||||
1 | Glioblastoma | MT1 175; | MT1 > MT2 | MT1 = MT2 | A1/A2 | C/G | C | L1-2 | A1 | G | A2 MT1 |
CGC > CAC | |||||||||||
Arg > His | |||||||||||
MT2 282 | |||||||||||
CGG > TGG | |||||||||||
Arg > Trp | |||||||||||
2 | Glioblastoma | 237; ATG > ATA Met > Ile | MT | WT > MT | A1/A2 | C/G | C | L2-2 | A1 | G | A2 MT |
13 | Soft tissue sarcoma | 216; GTG > ATG Val > Met | MT | MT > WT | A1/A2 | C/G | C | L3-1 L3-2 | A2 | C | A2 MT |
20 | Colorectal cancer | 248; CGG > CAG Arg > Gln | MT | WT > MT | A1/A2 | C/G | G | L4-2 | A1 | C | A2 MT |
21 | Colorectal cancer | 273; CGT > CAT Arg > His | MT > WT | WT > MT | A1/A2 | C/G | C | L5-1 L5-2 | A2 | C | A2 MT |
30 | Prostate cancer | 239; AAC > GAC Asn > Asp | MT | MT = WT | A1/A2 | C/G | C | L6-2 | A2 | C | A2 MT |