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Table 1 Results of DNA and cDNA sequencing analysis in samples with TP53 mutations [2, 3, 19, 20]

From: PIN3 duplication may be partially responsible for TP53haploinsufficiency

No. Diagnosis TP53mutations PIN3 status 72 codon status
Location/type cDNA DNA
TP53 mutations; cases showing discrepancies between cDNA and DNA
1 Glioblastoma MT1 175; CGC > CAC; Arg > His MT1 > MT2 MT1 = MT2 A1/A2 C/G
MT2 282; CGG > TGG; Arg > Trp
2 Glioblastoma 237; ATG > ATA; Met > Ile MT WT > MT A1/A2 C/G
3 Glioblastoma 273; CGT > CAT; Arg > His MT WT > MT A1 C
4 Glioblastoma 234; TAC > CAC; Tyr > His MT WT > MT A1 G
5 Glioblastoma 273; CGT > TGT; Arg > Cys MT WT > MT A1 G
6 Glioblastoma 190; CCT > TCT; Pro > Ser MT WT = MT A1 G
7 Glioblastoma 152; CCG > CTG; Pro > Leu MT WT = MT A2 C
8 Glioblastoma 273; CGT > TGT; Arg > Cys MT WT = MT A2 G
9 Glioblastoma 237; ATG > ATA; Met > Ile MT MT > WT A1 C
10 Glioblastoma 161; GCC > ACC; Ala > Thr MT MT > WT A2 C/G
11 Soft tissue sarcoma 248; CGG > CAG; Arg > Gln MT WT A1 G
12 Soft tissue sarcoma 273; CGT > TGT; Arg > Cys MT WT = MT A1 G
13 Soft tissue sarcoma 216; GTG > ATG; Val > Met MT MT > WT A1/A2 C/G
14 Colorectal cancer 173; GTG > ATG; Val > Met MT MT > WT A1 G
15 Colorectal cancer 248; CGG > TGG; Arg > Trp MT WT A1 C/G
16 Colorectal cancer 175; CGC > CAC; Arg > His MT WT = MT A1 G
17 Colorectal cancer 273; CGT > CAT; Arg > His MT > WT WT = MT A1 G
18 Colorectal cancer 285; GAG > AAG; Glu > Lys MT > WT WT A1 G
19 Colorectal cancer 245; GGC > AGC; Gly > Ser MT WT > MT A2 C
20 Colorectal cancer 248; CGG > CAG; Arg > Gln MT WT > MT A1/A2 C/G
21 Colorectal cancer 273; CGT > CAT; Arg > His MT > WT WT > MT A1/A2 C/G
22 Colorectal cancer 282; CGG > TGG; Arg > Trp MT WT > MT A1 G
23 Colorectal cancer 245; GGC > AGC; Gly > Ser MT = WT WT > MT A1 G
24 Colorectal cancer 216; GTG > ATG; Val > Met MT > WT WT = MT A1 G
25 Colorectal cancer 245; GGC > AGC; Gly > Ser MT = WT WT > MT A1 G
26 Colorectal cancer 175; CGC > CAC; Arg > His MT WT = MT A1 G
27 Colorectal cancer 175; CGC > CAC; Arg > His MT MT > WT A2 C/G
28 Leukemia (AML) 216; GTG > ATG; Val > Met MT WT A1 C/G
29 Leukemia (AML) 267; CGG > GGG; Arg > Gly MT = WT WT A1 C/G
30 Prostate cancer 239; AAC > GAC; Asn > Asp MT WT = MT A1/A2 C/G
TP53 mutations; no discrepancies between DNA and cDNA sequencing
31 Glioblastoma 214; AGT > AAT; Ser > Asn WT = MT WT = MT A1 G
32 Glioblastoma 282; CGG > TGG; Arg > Trp WT = MT WT = MT A1 G
33 Astrocytoma 179; CAT > GAT; His > Asp WT = MT WT = MT A1 C/G
34 Glioblastoma 267; CGG > TGG; Pro > Trp WT = MT WT = MT A1 C/G
35 Glioblastoma 173; GTG > TTG; Val > Leu WT = MT WT = MT A1 G
36 Glioblastoma 273; CGT > TGT; Arg > Cys WT = MT WT = MT A1 G
37 Glioblastoma 190; CCT > CTT; Pro > Leu WT = MT WT = MT A2 C
38 Glioblastoma 145; CTG > CAG; Leu > Gln MT MT A1 C
39 Soft tissue sarcoma 273; CGT > TGT; Arg > Cys WT = MT WT = MT A1 G
40 Soft tissue sarcoma 215; AGT > AAA; Ser > Lys MT > WT MT > WT A1 C/G
41 Soft tissue sarcoma 248; CGG > CAG; Arg > Gln MT MT A1 G
42 Soft tissue sarcoma 173; GTG > TTG; Val > Leu MT MT A1/A2 C/G
43 Colorectal cancer 273; CGT > CAT; Arg > His WT = MT WT = MT A1 C
44 Colorectal cancer 134; TTT > CTT; Phe > Leu WT = MT WT = MT A1 C/G
45 Colorectal cancer 175; CGC > CAC; Arg > His WT = MT WT = MT A1 C/G
  1. AML – acute myeloid leukemia; WT – wild-type template; MT – mutated template; A1, A2 – polymorphic variants of PIN3; C – cytosine; G – guanine.