Skip to main content

Table 1 Results of DNA and cDNA sequencing analysis in samples with TP53 mutations [2, 3, 19, 20]

From: PIN3 duplication may be partially responsible for TP53haploinsufficiency

No.

Diagnosis

TP53mutations

PIN3 status

72 codon status

Location/type

cDNA

DNA

TP53 mutations; cases showing discrepancies between cDNA and DNA

1

Glioblastoma

MT1 175; CGC > CAC; Arg > His

MT1 > MT2

MT1 = MT2

A1/A2

C/G

MT2 282; CGG > TGG; Arg > Trp

2

Glioblastoma

237; ATG > ATA; Met > Ile

MT

WT > MT

A1/A2

C/G

3

Glioblastoma

273; CGT > CAT; Arg > His

MT

WT > MT

A1

C

4

Glioblastoma

234; TAC > CAC; Tyr > His

MT

WT > MT

A1

G

5

Glioblastoma

273; CGT > TGT; Arg > Cys

MT

WT > MT

A1

G

6

Glioblastoma

190; CCT > TCT; Pro > Ser

MT

WT = MT

A1

G

7

Glioblastoma

152; CCG > CTG; Pro > Leu

MT

WT = MT

A2

C

8

Glioblastoma

273; CGT > TGT; Arg > Cys

MT

WT = MT

A2

G

9

Glioblastoma

237; ATG > ATA; Met > Ile

MT

MT > WT

A1

C

10

Glioblastoma

161; GCC > ACC; Ala > Thr

MT

MT > WT

A2

C/G

11

Soft tissue sarcoma

248; CGG > CAG; Arg > Gln

MT

WT

A1

G

12

Soft tissue sarcoma

273; CGT > TGT; Arg > Cys

MT

WT = MT

A1

G

13

Soft tissue sarcoma

216; GTG > ATG; Val > Met

MT

MT > WT

A1/A2

C/G

14

Colorectal cancer

173; GTG > ATG; Val > Met

MT

MT > WT

A1

G

15

Colorectal cancer

248; CGG > TGG; Arg > Trp

MT

WT

A1

C/G

16

Colorectal cancer

175; CGC > CAC; Arg > His

MT

WT = MT

A1

G

17

Colorectal cancer

273; CGT > CAT; Arg > His

MT > WT

WT = MT

A1

G

18

Colorectal cancer

285; GAG > AAG; Glu > Lys

MT > WT

WT

A1

G

19

Colorectal cancer

245; GGC > AGC; Gly > Ser

MT

WT > MT

A2

C

20

Colorectal cancer

248; CGG > CAG; Arg > Gln

MT

WT > MT

A1/A2

C/G

21

Colorectal cancer

273; CGT > CAT; Arg > His

MT > WT

WT > MT

A1/A2

C/G

22

Colorectal cancer

282; CGG > TGG; Arg > Trp

MT

WT > MT

A1

G

23

Colorectal cancer

245; GGC > AGC; Gly > Ser

MT = WT

WT > MT

A1

G

24

Colorectal cancer

216; GTG > ATG; Val > Met

MT > WT

WT = MT

A1

G

25

Colorectal cancer

245; GGC > AGC; Gly > Ser

MT = WT

WT > MT

A1

G

26

Colorectal cancer

175; CGC > CAC; Arg > His

MT

WT = MT

A1

G

27

Colorectal cancer

175; CGC > CAC; Arg > His

MT

MT > WT

A2

C/G

28

Leukemia (AML)

216; GTG > ATG; Val > Met

MT

WT

A1

C/G

29

Leukemia (AML)

267; CGG > GGG; Arg > Gly

MT = WT

WT

A1

C/G

30

Prostate cancer

239; AAC > GAC; Asn > Asp

MT

WT = MT

A1/A2

C/G

TP53 mutations; no discrepancies between DNA and cDNA sequencing

31

Glioblastoma

214; AGT > AAT; Ser > Asn

WT = MT

WT = MT

A1

G

32

Glioblastoma

282; CGG > TGG; Arg > Trp

WT = MT

WT = MT

A1

G

33

Astrocytoma

179; CAT > GAT; His > Asp

WT = MT

WT = MT

A1

C/G

34

Glioblastoma

267; CGG > TGG; Pro > Trp

WT = MT

WT = MT

A1

C/G

35

Glioblastoma

173; GTG > TTG; Val > Leu

WT = MT

WT = MT

A1

G

36

Glioblastoma

273; CGT > TGT; Arg > Cys

WT = MT

WT = MT

A1

G

37

Glioblastoma

190; CCT > CTT; Pro > Leu

WT = MT

WT = MT

A2

C

38

Glioblastoma

145; CTG > CAG; Leu > Gln

MT

MT

A1

C

39

Soft tissue sarcoma

273; CGT > TGT; Arg > Cys

WT = MT

WT = MT

A1

G

40

Soft tissue sarcoma

215; AGT > AAA; Ser > Lys

MT > WT

MT > WT

A1

C/G

41

Soft tissue sarcoma

248; CGG > CAG; Arg > Gln

MT

MT

A1

G

42

Soft tissue sarcoma

173; GTG > TTG; Val > Leu

MT

MT

A1/A2

C/G

43

Colorectal cancer

273; CGT > CAT; Arg > His

WT = MT

WT = MT

A1

C

44

Colorectal cancer

134; TTT > CTT; Phe > Leu

WT = MT

WT = MT

A1

C/G

45

Colorectal cancer

175; CGC > CAC; Arg > His

WT = MT

WT = MT

A1

C/G

  1. AML – acute myeloid leukemia; WT – wild-type template; MT – mutated template; A1, A2 – polymorphic variants of PIN3; C – cytosine; G – guanine.