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Table 1 Clinical characteristics of training and validation sets

From: Postoperative nomogram to predict the probability of metastasis in Enneking stage IIB extremity osteosarcoma

Variables Training (N= 91) Validation (N= 34)
  N % N %
Survival 5 years survivor (CDF from definitive surgery) 58 63.7 16 47.1
  5 years survivor (NED after metastasectomy) 6 6.6 2 5.9
  DOD 27 29.7 7 20.6
  NED (after metastasectomy) < 5 years 0 0.0 6 17.6
  AWD 0 0.0 2 5.9
  DOC 0 0.0 1 2.9
Metastasis Positive 34 37.4 17 50.0
  Free 57 62.6 17 50.0
Sex Male 50 54.9 19 55.9
  Female 41 45.1 15 44.1
Age ≤ 14 yrs 36 39.6 17 50.0
  > 15 yrs 55 60.4 17 50.0
Tumor site Distal femur 46 50.5 12 35.3
  Proximal tibia 17 18.7 7 20.6
  Proximal humerus 14 15.4 5 14.7
  Others 14 15.4 10 29.4
Tumor size ≥ 8cm 62 68.1 20 58.8
  < 8cm 29 31.9 14 41.2
Pathologic fx at diagnosis Yes 5 5.5 2 5.9
  No 86 94.5 32 94.1
Skip lesion Yes 3 3.3 2 5.9
  No 88 96.7 32 94.1
Intracapsular extension Yes 20 22.0 10 29.4
  No 71 78.0 24 70.6
ALP Elevation 56 61.5 11 32.4
  Normal 35 38.5 23 67.6
LDH Elevation 9 9.9 5 14.7
  Normal 53 58.2 16 47.1
  NA 29 31.9 13 38.2
Histologic type Osteoblastic 62 68.1 17 50.0
  Chondroblastic 11 12.1 3 8.8
  Fibroblastic 4 4.4 1 2.9
  Mixed 12 13.2 5 14.7
  Others 2 2.2 3 8.8
  NA 0 0.0 5 14.7
Huvos grade III and IV 65 71.4 21 61.8
  I and II 26 28.6 13 38.2
Operation Type Limb salvage surgery 91 100.0 23 67.6
  Amputation 0 0.0 11 32.4
Surgeon factor Surgeon 1 91 100.0 22 64.7
  Surgeon 2 0 0.0 10 29.4
  Surgeon 3 0 0.0 2 5.9
Surgical resection R0 85 93.4 33 97.1
  R1 6 6.6 1 2.9
  1. Abbreviation: CDF, continuously disease free, DOD, died of disease, NED, no evidence of disease, AWD, alive with metastatic disease, DOC, died of other cause, fx, fracture, ALP, alkaline phosphatase, LDH, lactate dehydrogenase, NA, not available.