|
Variables
|
Training (N= 91)
|
Validation (N= 34)
|
|---|
| |
N
|
%
|
N
|
%
|
|---|
|
Survival
|
5 years survivor (CDF from definitive surgery)
|
58
|
63.7
|
16
|
47.1
|
| |
5 years survivor (NED after metastasectomy)
|
6
|
6.6
|
2
|
5.9
|
| |
DOD
|
27
|
29.7
|
7
|
20.6
|
| |
NED (after metastasectomy) < 5 years
|
0
|
0.0
|
6
|
17.6
|
| |
AWD
|
0
|
0.0
|
2
|
5.9
|
| |
DOC
|
0
|
0.0
|
1
|
2.9
|
|
Metastasis
|
Positive
|
34
|
37.4
|
17
|
50.0
|
| |
Free
|
57
|
62.6
|
17
|
50.0
|
|
Sex
|
Male
|
50
|
54.9
|
19
|
55.9
|
| |
Female
|
41
|
45.1
|
15
|
44.1
|
|
Age
|
≤ 14 yrs
|
36
|
39.6
|
17
|
50.0
|
| |
> 15 yrs
|
55
|
60.4
|
17
|
50.0
|
|
Tumor site
|
Distal femur
|
46
|
50.5
|
12
|
35.3
|
| |
Proximal tibia
|
17
|
18.7
|
7
|
20.6
|
| |
Proximal humerus
|
14
|
15.4
|
5
|
14.7
|
| |
Others
|
14
|
15.4
|
10
|
29.4
|
|
Tumor size
|
≥ 8cm
|
62
|
68.1
|
20
|
58.8
|
| |
< 8cm
|
29
|
31.9
|
14
|
41.2
|
|
Pathologic fx at diagnosis
|
Yes
|
5
|
5.5
|
2
|
5.9
|
| |
No
|
86
|
94.5
|
32
|
94.1
|
|
Skip lesion
|
Yes
|
3
|
3.3
|
2
|
5.9
|
| |
No
|
88
|
96.7
|
32
|
94.1
|
|
Intracapsular extension
|
Yes
|
20
|
22.0
|
10
|
29.4
|
| |
No
|
71
|
78.0
|
24
|
70.6
|
|
ALP
|
Elevation
|
56
|
61.5
|
11
|
32.4
|
| |
Normal
|
35
|
38.5
|
23
|
67.6
|
|
LDH
|
Elevation
|
9
|
9.9
|
5
|
14.7
|
| |
Normal
|
53
|
58.2
|
16
|
47.1
|
| |
NA
|
29
|
31.9
|
13
|
38.2
|
|
Histologic type
|
Osteoblastic
|
62
|
68.1
|
17
|
50.0
|
| |
Chondroblastic
|
11
|
12.1
|
3
|
8.8
|
| |
Fibroblastic
|
4
|
4.4
|
1
|
2.9
|
| |
Mixed
|
12
|
13.2
|
5
|
14.7
|
| |
Others
|
2
|
2.2
|
3
|
8.8
|
| |
NA
|
0
|
0.0
|
5
|
14.7
|
|
Huvos grade
|
III and IV
|
65
|
71.4
|
21
|
61.8
|
| |
I and II
|
26
|
28.6
|
13
|
38.2
|
|
Operation Type
|
Limb salvage surgery
|
91
|
100.0
|
23
|
67.6
|
| |
Amputation
|
0
|
0.0
|
11
|
32.4
|
|
Surgeon factor
|
Surgeon 1
|
91
|
100.0
|
22
|
64.7
|
| |
Surgeon 2
|
0
|
0.0
|
10
|
29.4
|
| |
Surgeon 3
|
0
|
0.0
|
2
|
5.9
|
|
Surgical resection
|
R0
|
85
|
93.4
|
33
|
97.1
|
| |
R1
|
6
|
6.6
|
1
|
2.9
|
- Abbreviation: CDF, continuously disease free, DOD, died of disease, NED, no evidence of disease, AWD, alive with metastatic disease, DOC, died of other cause, fx, fracture, ALP, alkaline phosphatase, LDH, lactate dehydrogenase, NA, not available.
