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Table 1 Clinical characteristics of training and validation sets

From: Postoperative nomogram to predict the probability of metastasis in Enneking stage IIB extremity osteosarcoma

Variables

Training (N= 91)

Validation (N= 34)

Ā 

N

%

N

%

Survival

5 years survivor (CDF from definitive surgery)

58

63.7

16

47.1

Ā 

5 years survivor (NED after metastasectomy)

6

6.6

2

5.9

Ā 

DOD

27

29.7

7

20.6

Ā 

NED (after metastasectomy) < 5 years

0

0.0

6

17.6

Ā 

AWD

0

0.0

2

5.9

Ā 

DOC

0

0.0

1

2.9

Metastasis

Positive

34

37.4

17

50.0

Ā 

Free

57

62.6

17

50.0

Sex

Male

50

54.9

19

55.9

Ā 

Female

41

45.1

15

44.1

Age

ā‰¤ 14 yrs

36

39.6

17

50.0

Ā 

> 15 yrs

55

60.4

17

50.0

Tumor site

Distal femur

46

50.5

12

35.3

Ā 

Proximal tibia

17

18.7

7

20.6

Ā 

Proximal humerus

14

15.4

5

14.7

Ā 

Others

14

15.4

10

29.4

Tumor size

ā‰„ 8cm

62

68.1

20

58.8

Ā 

< 8cm

29

31.9

14

41.2

Pathologic fx at diagnosis

Yes

5

5.5

2

5.9

Ā 

No

86

94.5

32

94.1

Skip lesion

Yes

3

3.3

2

5.9

Ā 

No

88

96.7

32

94.1

Intracapsular extension

Yes

20

22.0

10

29.4

Ā 

No

71

78.0

24

70.6

ALP

Elevation

56

61.5

11

32.4

Ā 

Normal

35

38.5

23

67.6

LDH

Elevation

9

9.9

5

14.7

Ā 

Normal

53

58.2

16

47.1

Ā 

NA

29

31.9

13

38.2

Histologic type

Osteoblastic

62

68.1

17

50.0

Ā 

Chondroblastic

11

12.1

3

8.8

Ā 

Fibroblastic

4

4.4

1

2.9

Ā 

Mixed

12

13.2

5

14.7

Ā 

Others

2

2.2

3

8.8

Ā 

NA

0

0.0

5

14.7

Huvos grade

III and IV

65

71.4

21

61.8

Ā 

I and II

26

28.6

13

38.2

Operation Type

Limb salvage surgery

91

100.0

23

67.6

Ā 

Amputation

0

0.0

11

32.4

Surgeon factor

Surgeon 1

91

100.0

22

64.7

Ā 

Surgeon 2

0

0.0

10

29.4

Ā 

Surgeon 3

0

0.0

2

5.9

Surgical resection

R0

85

93.4

33

97.1

Ā 

R1

6

6.6

1

2.9

  1. Abbreviation: CDF, continuously disease free, DOD, died of disease, NED, no evidence of disease, AWD, alive with metastatic disease, DOC, died of other cause, fx, fracture, ALP, alkaline phosphatase, LDH, lactate dehydrogenase, NA, not available.