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Table 2 Parameters of the multivariate (Cox model) analysis of clinicopathological factors

From: Epstein-Barr virus infection and clinical outcome in breast cancer patients correlate with immune cell TNF-α/IFN-γ response

Explicative variables Relative risk (95% CI) p-value
EBV-T + 2.36.104 (152.9-3.7 106) <0.0001
Grade 11.52 (2.28-58.28) 0.003
EBV-P + 122 (1.5-9.8 103) 0.03
Lymph node invasion 16.59 (2.5-110) 0.004
EBV-T + : grade 0.0082 (0.00071-0.0094) 0.0001
EBV-P + : HER-2 254 (7.88–8.19 103) 0.002
EBV-P + : grade 0.16 (0.03-0.96) 0.045
  1. EBV: Epstein-Barr virus; T+: detected in tumors; P+: detected in PBMCs; HER-2: human epidermal growth factor receptor 2.
  2. The hazard function for the model with EBV variables reads as: h 2 t = h 0 t | Relapse ×exp β 21 × Lymp + β 22 × EBV P + β 23 × EBV T + β 24 × Grade + γ 1 × EBV P : Grade + γ 2 × EBV T : Grade + γ 3 × EBV P : HER 2 .
  3. The relative risk (RR) >1 corresponds to a negative effect, i.e. a decrease in patient survival, while an RR <1 corresponds to a positive effect, i.e. an increase in patient survival. “95% CI” stands for the confidence interval at 95%. The variable “Grade” includes all grades.