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Table 3 Subgroup analysis of breast cancer risk according to family history of selected cancers
| Site | HR positive* | HR negative* | ≤ 50 y* | > 50 y* | ||||
|---|---|---|---|---|---|---|---|---|
| Cases/control (n/n) | OR (95% CI) | Cases/control (n/n) | OR (95% CI) | Cases/control (n/n) | OR (95% CI) | Cases/control (n/n) | OR (95% CI) | |
| breast | 12/16 | 1.69 (0.69 – 4.17) | 9/16 | 3.59 (1.36 – 9.47) | 12/16 | 2.23 (0.81 – 6.14) | 14/16 | 2.43 (0.73 – 8.20) |
| Lung | 17/13 | 3.37 (1.45 – 7.82) | 4/13 | 1.30 (0.33 – 5.14) | 11/13 | 2.01 (0.70 – 5.79) | 10/13 | 3.24 (0.85 – 12.42) |
| Esophagus | 7/7 | 1.56 (0.53 – 4.55) | 11/7 | 6.19 (2.30 – 16.71) | 10/7 | 2.64 (0.81 – 8.66) | 8/7 | 2.50 (0.65 – 9.67) |
| Stomach | 15/17 | 1.69 (0.80 – 3.60) | 4/17 | 0.65 (0.18 – 2.39) | 8/17 | 1.10 (0.40 – 3.03) | 11/17 | 1.49 (0.51 – 4.32) |
| Intestine | 6/8 | 1.21 (0.37 – 3.95) | 1/8 | 0.55 (0.06 – 4.68) | 4/8 | 0.72 (0.15 – 3.36) | 3/8 | 1.16 (0.22 – 6.11) |
| Liver | 6/5 | 2.29 (0.68 – 7.70) | 4/5 | 2.95 (0.74 – 11.84) | 4/5 | 1.66 (0.37 – 7.53) | 6/5 | 2.82 (0.55 – 14.58) |
| Pancreas | 4/5 | 1.53 (0.40 – 5.84) | 2/5 | 1.57 (0.28 – 8.66) | 4/5 | 5.07 (0.56 – 45.84) | 2/5 | 0.51 (0.09 – 2.91) |
| Gallbladder | 1/2 | 2.14 (0.13 – 35.41) | / | / | / | / | / | / |
| Larynx | 4/2 | 5.19 (0.53 – 50.70) | / | / | / | / | 2/2 | 1.83 (0.16 – 20.55) |
| Bladder | 1/5 | 0.41 (0.05 – 3.71) | / | / | 1/5 | 0.39 (0.04 – 3.81) | / | / |
| Kidney | 2/1 | 3.12 (0.28 – 35.11) | / | / | 2/1 | 1.93 (0.17 – 21.76) | / | / |
| Prostate | 1/2 | 2.78 (0.17 – 46.34) | / | / | / | / | / | / |
| Uterus | 4/3 | 3.23 (0.58 – 17.98) | 3/3 | 6.92 (1.12 – 42.89) | 2/3 | 1.11 (0.15 – 8.11) | / | / |
| Appendix | 1/2 | 1.83 (0.11 – 30.22) | 1/2 | 6.01 (0.36 – 101.25) | / | / | 1/2 | 0.99 (0.06 – 16.34) |
| Lymphoma | 4/3 | 5.26 (0.54 – 51.20) | 1/3 | 4.64 (0.28 – 78.24) | 2/3 | 1.37 (0.09 – 22.14) | / | / |
| Digestive tract | 27/30 | 1.57 (0.89 – 2.77) | 16/30 | 2.05 (1.03 – 4.10) | 22/30 | 1.49 (0.74 – 3.00) | 21/30 | 1.63 (0.77 – 3.49) |
| Digestive system | 37/39 | 1.79 (1.09 – 2.93) | 22/39 | 2.29 (1.26 – 4.17) | 31/39 | 1.88 (1.03 – 3.43) | 28/39 | 1.67 (0.86 – 3.25) |
| Urinary system | 4/8 | 1.19 (0.33 – 4.31) | / | / | 4/8 | 1.12 (0.27 – 4.58) | / | / |
| Hematological system | 4/6 | 1.78 (0.35 – 8.94) | 2/6 | 3.02 (0.48 – 18.88) | 3/6 | 0.75 (0.12 – 4.64) | / | / |
| Gynecology | 5/5 | 2.78 (0.65 – 11.87) | 4/5 | 6.79 (1.46 – 31.65) | 3/5 | 1.74 (0.28 – 10.66) | 6/5 | 6.16 (0.73 – 52.15) |
| Two or more histories# | 4/11 | 0.96 (0.27 – 3.39) | 1/11 | 0.58 (0.07 – 4.92) | / | / | 5/11 | 1.54 (0.35 – 6.65) |
| All sites# | 73/70 | 2.36 (1.60 – 3.47) | 32/70 | 2.29 (1.38 – 3.78) | 58/70 | 1.92 (1.21 – 3.05) | 48/70 | 2.39 (1.36 – 4.20) |
