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Table 3 Subgroup analysis of breast cancer risk according to family history of selected cancers

From: Risk of breast cancer and family history of other cancers in first-degree relatives in Chinese women: a case control study

Site

HR positive*

HR negative*

≤ 50 y*

> 50 y*

 

Cases/control (n/n)

OR (95% CI)

Cases/control (n/n)

OR (95% CI)

Cases/control (n/n)

OR (95% CI)

Cases/control (n/n)

OR (95% CI)

breast

12/16

1.69 (0.69 – 4.17)

9/16

3.59 (1.36 – 9.47)

12/16

2.23 (0.81 – 6.14)

14/16

2.43 (0.73 – 8.20)

Lung

17/13

3.37 (1.45 – 7.82)

4/13

1.30 (0.33 – 5.14)

11/13

2.01 (0.70 – 5.79)

10/13

3.24 (0.85 – 12.42)

Esophagus

7/7

1.56 (0.53 – 4.55)

11/7

6.19 (2.30 – 16.71)

10/7

2.64 (0.81 – 8.66)

8/7

2.50 (0.65 – 9.67)

Stomach

15/17

1.69 (0.80 – 3.60)

4/17

0.65 (0.18 – 2.39)

8/17

1.10 (0.40 – 3.03)

11/17

1.49 (0.51 – 4.32)

Intestine

6/8

1.21 (0.37 – 3.95)

1/8

0.55 (0.06 – 4.68)

4/8

0.72 (0.15 – 3.36)

3/8

1.16 (0.22 – 6.11)

Liver

6/5

2.29 (0.68 – 7.70)

4/5

2.95 (0.74 – 11.84)

4/5

1.66 (0.37 – 7.53)

6/5

2.82 (0.55 – 14.58)

Pancreas

4/5

1.53 (0.40 – 5.84)

2/5

1.57 (0.28 – 8.66)

4/5

5.07 (0.56 – 45.84)

2/5

0.51 (0.09 – 2.91)

Gallbladder

1/2

2.14 (0.13 – 35.41)

/

/

/

/

/

/

Larynx

4/2

5.19 (0.53 – 50.70)

/

/

/

/

2/2

1.83 (0.16 – 20.55)

Bladder

1/5

0.41 (0.05 – 3.71)

/

/

1/5

0.39 (0.04 – 3.81)

/

/

Kidney

2/1

3.12 (0.28 – 35.11)

/

/

2/1

1.93 (0.17 – 21.76)

/

/

Prostate

1/2

2.78 (0.17 – 46.34)

/

/

/

/

/

/

Uterus

4/3

3.23 (0.58 – 17.98)

3/3

6.92 (1.12 – 42.89)

2/3

1.11 (0.15 – 8.11)

/

/

Appendix

1/2

1.83 (0.11 – 30.22)

1/2

6.01 (0.36 – 101.25)

/

/

1/2

0.99 (0.06 – 16.34)

Lymphoma

4/3

5.26 (0.54 – 51.20)

1/3

4.64 (0.28 – 78.24)

2/3

1.37 (0.09 – 22.14)

/

/

Digestive tract

27/30

1.57 (0.89 – 2.77)

16/30

2.05 (1.03 – 4.10)

22/30

1.49 (0.74 – 3.00)

21/30

1.63 (0.77 – 3.49)

Digestive system

37/39

1.79 (1.09 – 2.93)

22/39

2.29 (1.26 – 4.17)

31/39

1.88 (1.03 – 3.43)

28/39

1.67 (0.86 – 3.25)

Urinary system

4/8

1.19 (0.33 – 4.31)

/

/

4/8

1.12 (0.27 – 4.58)

/

/

Hematological system

4/6

1.78 (0.35 – 8.94)

2/6

3.02 (0.48 – 18.88)

3/6

0.75 (0.12 – 4.64)

/

/

Gynecology

5/5

2.78 (0.65 – 11.87)

4/5

6.79 (1.46 – 31.65)

3/5

1.74 (0.28 – 10.66)

6/5

6.16 (0.73 – 52.15)

Two or more histories#

4/11

0.96 (0.27 – 3.39)

1/11

0.58 (0.07 – 4.92)

/

/

5/11

1.54 (0.35 – 6.65)

All sites#

73/70

2.36 (1.60 – 3.47)

32/70

2.29 (1.38 – 3.78)

58/70

1.92 (1.21 – 3.05)

48/70

2.39 (1.36 – 4.20)

  1. HR, Hormone receptor; *Adjusted for age, age at menarche, childbearing, menopause status; #family history of breast cancer was excluded; bold data reflected P < 0.05.