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Table 3 Subgroup analysis of breast cancer risk according to family history of selected cancers

From: Risk of breast cancer and family history of other cancers in first-degree relatives in Chinese women: a case control study

Site HR positive* HR negative* ≤ 50 y* > 50 y*
  Cases/control (n/n) OR (95% CI) Cases/control (n/n) OR (95% CI) Cases/control (n/n) OR (95% CI) Cases/control (n/n) OR (95% CI)
breast 12/16 1.69 (0.69 – 4.17) 9/16 3.59 (1.36 – 9.47) 12/16 2.23 (0.81 – 6.14) 14/16 2.43 (0.73 – 8.20)
Lung 17/13 3.37 (1.45 – 7.82) 4/13 1.30 (0.33 – 5.14) 11/13 2.01 (0.70 – 5.79) 10/13 3.24 (0.85 – 12.42)
Esophagus 7/7 1.56 (0.53 – 4.55) 11/7 6.19 (2.30 – 16.71) 10/7 2.64 (0.81 – 8.66) 8/7 2.50 (0.65 – 9.67)
Stomach 15/17 1.69 (0.80 – 3.60) 4/17 0.65 (0.18 – 2.39) 8/17 1.10 (0.40 – 3.03) 11/17 1.49 (0.51 – 4.32)
Intestine 6/8 1.21 (0.37 – 3.95) 1/8 0.55 (0.06 – 4.68) 4/8 0.72 (0.15 – 3.36) 3/8 1.16 (0.22 – 6.11)
Liver 6/5 2.29 (0.68 – 7.70) 4/5 2.95 (0.74 – 11.84) 4/5 1.66 (0.37 – 7.53) 6/5 2.82 (0.55 – 14.58)
Pancreas 4/5 1.53 (0.40 – 5.84) 2/5 1.57 (0.28 – 8.66) 4/5 5.07 (0.56 – 45.84) 2/5 0.51 (0.09 – 2.91)
Gallbladder 1/2 2.14 (0.13 – 35.41) / / / / / /
Larynx 4/2 5.19 (0.53 – 50.70) / / / / 2/2 1.83 (0.16 – 20.55)
Bladder 1/5 0.41 (0.05 – 3.71) / / 1/5 0.39 (0.04 – 3.81) / /
Kidney 2/1 3.12 (0.28 – 35.11) / / 2/1 1.93 (0.17 – 21.76) / /
Prostate 1/2 2.78 (0.17 – 46.34) / / / / / /
Uterus 4/3 3.23 (0.58 – 17.98) 3/3 6.92 (1.12 – 42.89) 2/3 1.11 (0.15 – 8.11) / /
Appendix 1/2 1.83 (0.11 – 30.22) 1/2 6.01 (0.36 – 101.25) / / 1/2 0.99 (0.06 – 16.34)
Lymphoma 4/3 5.26 (0.54 – 51.20) 1/3 4.64 (0.28 – 78.24) 2/3 1.37 (0.09 – 22.14) / /
Digestive tract 27/30 1.57 (0.89 – 2.77) 16/30 2.05 (1.03 – 4.10) 22/30 1.49 (0.74 – 3.00) 21/30 1.63 (0.77 – 3.49)
Digestive system 37/39 1.79 (1.09 – 2.93) 22/39 2.29 (1.26 – 4.17) 31/39 1.88 (1.03 – 3.43) 28/39 1.67 (0.86 – 3.25)
Urinary system 4/8 1.19 (0.33 – 4.31) / / 4/8 1.12 (0.27 – 4.58) / /
Hematological system 4/6 1.78 (0.35 – 8.94) 2/6 3.02 (0.48 – 18.88) 3/6 0.75 (0.12 – 4.64) / /
Gynecology 5/5 2.78 (0.65 – 11.87) 4/5 6.79 (1.46 – 31.65) 3/5 1.74 (0.28 – 10.66) 6/5 6.16 (0.73 – 52.15)
Two or more histories# 4/11 0.96 (0.27 – 3.39) 1/11 0.58 (0.07 – 4.92) / / 5/11 1.54 (0.35 – 6.65)
All sites# 73/70 2.36 (1.60 – 3.47) 32/70 2.29 (1.38 – 3.78) 58/70 1.92 (1.21 – 3.05) 48/70 2.39 (1.36 – 4.20)
  1. HR, Hormone receptor; *Adjusted for age, age at menarche, childbearing, menopause status; #family history of breast cancer was excluded; bold data reflected P < 0.05.