Figure 2From: Characterization of the rs2802292 SNP identifies FOXO3Aas a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes GG genotype is associated with increased expression of FoxO3A both at the mRNA and protein level. HT-29, LS174T, HCT-116 and Caco-2 human intestinal cells were typed for the rs2802292 polymorphism and then analyzed by quantitative real-time PCR (A) and immunoblotting (B) to measure FoxO3A mRNA and protein expression. β-Actin was used as a loading control.Back to article page