Figure 1From: Characterization of the rs2802292 SNP identifies FOXO3Aas a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes Our study is based on a ‘signal transduction’ hypothesis, which relies on the crosstalk between LKB1/AMPK and PI3K/PTEN/Akt signaling at the level of FoxO3A. In particular, LKB1 activates AMPK, which in turn activates FoxO3A, while PTEN inhibits Akt, which in turn inhibits FoxO3A.Back to article page