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Table 1 Summary of the different case–control association studies targeting the mtDNA polymorphism m.10398A > G. statistical power was computed using mitPower

From: The saga of the many studies wrongly associating mitochondrial DNA with breast cancer

Reference Population/Ethnicity No. of cases No. of controls Power (%) ‘Risky’ allele
(frequency of A10398) (frequency of A10398)
[12] ‘African-Americans’ 48 (15%) 54 (6%) 15.1 None
  ‘African-Americans’ 654 (13%) 605 (9%) 98.4 A
  ‘Whites’ 879 (80%) 760 (79%) 100 None
[13, 19] Non-Jewish European American 156 (68%) 260 (79%) 66.1 G
[14] Tamil Nadu; South India 279 (38%) 280 (45%) 97.8 None
  Andhra Pradesh, South India 348 (46%) 352 (45%) 99.2 None
  Karnataka, South India 89 (38%) 92 (42%) 59.1 None
[5] Spanish mainland 464 (84%) 453 (82%) 94.9 None
  Canary Island (Spain) 302 (76%) 295 (78%) 88.5 None
[20] North India 124 (57%) 273 (44%) 85.6 A
[18] ‘African-American’ 542 (7%) 282 (4%) 49.4 None
  Multi-ethnic cohort 391 (7%) 460 (6%) 78.2 None
  CARE and LIFE cohort 524 (6%) 236 (7%) 72.1 None
[21] Polish 44 (77%) 100 (97%) 0.1 G
[22] Southern Chinese 28 (26.9%) 45 (39.5%) 25.3 None
[23] Bangladesh; India 24 (75%) 20 (35%) 16.7 A
[24] Iraq 21 (100%) 16 (100%) 11.2 None
  Iraq 21 (100%) 22 (91%) 0 None
[25] Malay 101 (27%) 90 (46%) 61.4 G