Figure 1

Statistical tests between artificial cases and controls in a simulation-based approach, where the amount of haplogroup K1 mtDNA profiles in cases is progressively increased with respect to controls. (A) P-values; (B) adjusted P-values (based on a permutation procedure); (C) odds ratio (OR) values. P-values are reported for (i) the Fisher exact test applied to mtSNP 10398G, 12308G, and haplogroup K1; and (ii) for the logistic regression interaction between mtSNPs 10398G and 12308G. The permutation analysis was not carried out in the interaction scenario (Figure 1B) because multiple test correction is not necessary as only a single test is carried out at the time.