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Table 3 Univariate and multivariate analysis of predictive miRNA for PFS and OS in metastatic colorectal cancer patients (Training Cohort)

From: MiR-107 and miR-99a-3p predict chemotherapy response in patients with advanced colorectal cancer

VARIABLES PFS OS
Univariate Analysis Multivariate Analysis Univariate Analysis Mutivariate Analysis
  HR (95% CI) p-value HR (95% CI) p-value HR (95% CI) p-value HR (95% CI) p-value
Age 0.99 [0.95-1.02] 0.357 0.99 [0.95-1.04] 0.765 1.01 [0.96-1.05] 0.746 1.06 [1.01-1.12] 0.027
Sex 0.51 [0.24-1.07] 0.069 0.60 [0.26-1.40] 0.232 0.42 [0.16-1.10] 0.069 0.17 [0.05-0.54] 0.003
miR-107 2.12 [1.05-4.29] 0.043 2.52 [1.18-5.42] 0.017 2.65 [1.06-6.67] 0.035 2.61 [0.86-7.92] 0.091
miR-337-5p 2.27 [1.12-4.58] 0.018 3.02 [1.34-6.83] 0.008 2.53 [0.95-6.80] 0.018 1.40 [0.42-4.69] 0.584
miR-99a-3p 2.34 [1.11-4.93] 0.030 2.50 [1.00-6.05] 0.050 3.46 [1.26-9.53] 0.008 1.99 [0.62-6.36] 0.243
miR-889 0.45 [0.22-0.94] 0.073 0.40 [0.16-0.90] 0.027 0.26 [0.10-0.71] 0.017 0.15 [0.04-0.47] 0.001
  1. PFS: progression free survival; OS: overall survival; CI: confidence interval; HR: Hazard Ratio.
  2. The bold value indicates a statistically significant result.