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Table 2 Cox proportional hazards multivariate regression model parameters

From: Prognostic model for predicting overall survival in children and adolescents with rhabdomyosarcoma

Covariate Beta coefficient Hazard ratio 95% CI p
Age -0.037* -** - 0.154
Age’ 0.089* -** - 0.013
Size 0.006 -†† - 0.095
Size’ -0.004 -†† - 0.359
Favorable site -0.204 0.82 0.65-1.02 0.076
Stage     
Regional 0.404 1.50 1.13-1.98 0.004
Distant 1.259 3.52 2.64-4.70 <0.001
Histology     
Alveolar 0.497 1.64 1.35-2.00 <0.001
Other -0.135 0.87 0.59-1.29 0.499
Received surgery -0.612 0.54 0.40-0.72 <0.001
Received RT -0.632 0.53 0.42-0.68 <0.001
Interaction terms     
Surgery × RT 0.564 1.75 1.24-2.50 0.002
  1. CI, confidence interval; RT, radiotherapy.
  2. *Age was modeled using a restricted cubic spline function with three knots, which yields two independent beta coefficients, annotated as Age and Age’.
  3. **The hazard ratio varies continuously with age.
  4. Size was modeled using a restricted cubic spline function with three knots, which yields two independent beta coefficients, annotated as Size and Size’.
  5. ††The hazard ratio varies continuously with size.