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Table 2 Incidence of CTC phenotypes according to differential expression patterns of ALDH1 and TWIST in patients with early and metastatic breast cancer

From: Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer

CTC phenotypes Patients (%) Percentage of CTCs per patient (mean; range) CTCs (%)
  Early Metastatic p value Early Metastatic p value Early Metastatic
ALDH1 high 30.8 80.0 0.009 23 (0–100) 75 (0–100) 0.001 38.7 83.5
ALDH1 low/neg 92.3 32.0 0.006 77 (0–100) 25 (0–100) 0.001 61.3 16.5
TWIST nuc 30.8 80.0 0.009 29 (0–100) 73 (0–100) 0.006 32.3 70.3
TWIST cyt/neg 76.9 40.0 0.040 71 (0–100) 27 (0–100) 0.006 67.7 29.7
  1. Chi-square test (Continuity Correction) and Mann Whitney test were used. Only patients with detectable CTCs were included; early setting: 13 patients and 31 CTCs; metastatic setting: 25 patients and 91 CTCs.